Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions

被引：0

作者：

Correa, Luana Barbosa ^{[1
,3
]}

Gomes-da-Silva, Natalia Cristina ^{[1
]}

dos Santos, Clenilton Costa ^{[2
]}

Alencar, Luciana Magalhaes Rebelo ^{[2
]}

Henriques, Maria das Gracas Muller de Oliveira ^{[3
]}

Bhattarai, Prapanna ^{[4
]}

Zhu, Lin ^{[4
]}

Souza, Pedro Filho Noronha ^{[5
]}

Rosas, Elaine Cruz ^{[3
,6
]}

Santos-Oliveira, Ralph ^{[1
,7
]}

机构：

[1] Brazilian Nucl Energy Commiss, Nucl Engn Inst, Lab Nanoradiopharm & Synth New Radiopharmaceut, BR-21941906 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Maranhao, Dept Phys, Biophys & Nanosyst Lab, BR-65065690 Sao Luis, MA, Brazil

[3] Fundacao Oswaldo Cruz, Lab Appl Pharmacol, Farmanguinhos, BR-21040360 Rio De Janeiro, Brazil

[4] Texas A&M Univ, Irma Lerma Rangel Sch Pharm, Dept Pharmaceut Sci, College Stn, TX 77843 USA

[5] Univ Fed Ceara, Drug Res & Dev Ctr, Dept Physiol & Pharmacol, BR-60430275 Fortaleza, CE, Brazil

[6] Farmanguinhos Oswaldo Cruz Fdn, Drugs Translat Res, BR-21040360 Rio De Janeiro, Brazil

[7] Univ Estado Rio De Janeiro, Lab Radiopharm & Nanoradiopharmaceut, BR-23070200 Rio De Janeiro, RJ, Brazil

来源：

THERAPEUTIC DELIVERY | 2024年 / 15卷 / 05期

关键词：

anti-inflammatory efficacy; cellular uptake; chia oil; drugs; inflammation; macrophage polarization; nanodrug; nanoemulsion; nutraceutical; therapy; INFLAMMATION; NANOPARTICLES; MOLECULES;

D O I：

10.4155/tde-2023-0088

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: This study explores chia oil, rich in omega-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. Methods/materials: A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. In vitro and in vivo assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. Results & conclusion: Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.

引用

页码：325 / 338

页数：14

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