A guideline on the molecular ecosystem regulating ferroptosis

被引：133

作者：

Dai, Enyong ^{[1
]}

Chen, Xin ^{[2
]}

Linkermann, Andreas ^{[3
,4
]}

Jiang, Xuejun ^{[5
]}

Kang, Rui ^{[6
]}

Kagan, Valerian E. ^{[7
]}

Bayir, Huelya ^{[8
]}

Yang, Wan Seok ^{[9
]}

Garcia-Saez, Ana J. ^{[10
]}

Ioannou, Maria S. ^{[11
]}

Janowitz, Tobias ^{[12
]}

Ran, Qitao ^{[13
]}

Gu, Wei ^{[14
,15
]}

Gan, Boyi ^{[16
]}

Krysko, Dmitri V. ^{[17
,18
]}

Zhu, Xiaofeng ^{[19
,20
]}

Wang, Jiayi ^{[21
,22
]}

Krautwald, Stefan ^{[23
]}

Toyokuni, Shinya ^{[24
,25
]}

Xie, Yangchun ^{[26
]}

Greten, Florian R. ^{[27
,28
,29
]}

Yi, Qing ^{[30
]}

Schick, Joel ^{[31
]}

Liu, Jiao ^{[32
]}

Gabrilovich, Dmitry I. ^{[33
]}

Liu, Jinbao ^{[2
]}

Zeh, Herbert J. ^{[6
]}

Zhang, Donna D. ^{[34
]}

Yang, Minghua ^{[35
,36
]}

Iovanna, Juan ^{[37
,38
]}

Kopf, Manfred ^{[39
]}

Adolph, Timon E. ^{[40
]}

Chi, Jen-Tsan ^{[41
]}

Li, Changfeng ^{[42
]}

Ichijo, Hidenori ^{[43
]}

Karin, Michael ^{[44
,45
]}

Sankaran, Vijay G. ^{[46
,47
,48
]}

Zou, Weiping ^{[49
,50
]}

Galluzzi, Lorenzo ^{[51
,52
,53
]}

Bush, Ashley I. ^{[54
]}

Li, Binghui ^{[55
,56
,57
,58
]}

Melino, Gerry ^{[59
]}

Baehrecke, Eric H. ^{[60
]}

Lotze, Michael T. ^{[61
,62
,63
]}

Klionsky, Daniel J. ^{[64
,65
]}

Stockwell, Brent R. ^{[66
,67
]}

Kroemer, Guido ^{[68
,69
,70
]}

Tang, Daolin ^{[6
]}

机构：

[1] Jilin Univ, Dept Oncol & Hematol, China Japan Union Hosp, Changchun, Peoples R China

[2] Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou Municipal & Guangdong Prov Key Lab Prot, Guangzhou, Peoples R China

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Div Nephrol, Dresden, Germany

[4] Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY 10467 USA

[5] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

[6] Univ Texas Southwestern Med Ctr, Dept Surg, Dallas, TX 75390 USA

[7] Univ Pittsburgh, Dept Environm Hlth, Pittsburgh, PA USA

[8] Columbia Univ, Dept Pediat, New York, NY USA

[9] St Johns Univ, Dept Biol Sci, New York, NY USA

[10] Univ Cologne, Inst Genet, CECAD, Cologne, Germany

[11] Univ Alberta, Dept Physiol, Edmonton, AB, Canada

[12] Cold Spring Harbor Lab, Cold Spring Harbor, NY USA

[13] South Texas Vet Hlth Care Syst, Dept Cell Syst & Anat, San Antonio, TX USA

[14] Columbia Univ, Inst Canc Genet, Vagelos Coll Phys & Surg, New York, NY USA

[15] Columbia Univ, Vagelos Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY USA

[16] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX USA

[17] Univ Ghent, Dept Human Struct & Repair, Cell Death Invest & Therapy CDIT Lab, Ghent, Belgium

[18] Canc Res Inst Ghent, Ghent, Belgium

[19] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Peoples R China

[20] Sun Yat Sen Univ, Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou, Peoples R China

[21] Shanghai Chest Hosp, Shanghai Inst Thorac Oncol, Dept Clin Lab, Shanghai, Peoples R China

[22] Shanghai Jiao Tong Univ, Coll Med Technol, Sch Med, Shanghai, Peoples R China

[23] Univ Hosp Schleswig Holstein, Dept Nephrol & Hypertens, Kiel, Germany

[24] Nagoya Univ, Grad Sch Med, Dept Pathol & Biol Response, Nagoya, Japan

[25] Nagoya Univ, Ctr Low Temp Plasma Sci, Nagoya, Japan

[26] Cent South Univ, Xiangya Hosp 2, Dept Oncol, Changsha, Peoples R China

[27] Georg Speyer Haus, Inst Tumor Biol & Expt Therapy, Frankfurt, Germany

[28] Goethe Univ, Frankfurt Canc Inst, Frankfurt, Germany

[29] German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[30] Houston Methodist Hosp, Houston Methodist Res Inst, Houston Methodist Neal Canc Ctr, Houston, TX USA

[31] Helmholtz Zentrum Munich, Inst Mol Toxicol & Pharmacol, Genet & Cellular Engn Grp, D-85764 Neuherberg, Germany

[32] Guangzhou Med Univ, Affiliated Hosp 3, DAMP Lab, Guangzhou, Peoples R China

[33] AstraZeneca, Early Oncol R&D, Gaithersburg, MD USA

[34] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[35] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha, Peoples R China

[36] Hunan Clin Res Ctr Pediat Canc, Changsha, Peoples R China

[37] Aix Marseille Univ, Ctr Rech Cancerol Marseille CRCM, CNRS UMR 7258, INSERM U1068, F-13288 Marseille, France

[38] Inst Paoli Calmettes, Marseille, France

[39] Swiss Fed Inst Technol, Inst Mol Hlth Sci, Dept Biol, Zurich, Switzerland

[40] Med Univ Innsbruck, Dept Internal Med Gastroenterol Hepatol Endocrinol, Innsbruck, Austria

[41] Duke Univ, Dept Mol Genet & Microbiol, Ctr Appl Genom & Technol, Durham, NC 27710 USA

[42] Jilin Univ, Dept Endoscopy Ctr, China Japan Union Hosp, Changchun, Peoples R China

[43] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Cell Signaling, Tokyo, Japan

[44] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA USA

[45] Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[46] Boston Childrens Hosp, Div Hematol Oncol, Boston, MA USA

[47] Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA USA

[48] Broad Inst MIT & Harvard, Cambridge, MA USA

[49] Univ Michigan, Med Sch, Dept Surg, Ann Arbor, MI USA

[50] Univ Michigan, Med Sch, Dept Pathol, Ann Arbor, MI USA

来源：

NATURE CELL BIOLOGY | 2024年 / 26卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CELL-DEATH; LIPID-PEROXIDATION; PROMOTES FERROPTOSIS; CANCER-CELLS; GPX4; PROTECTS; STRESS; SUSCEPTIBILITY; ACTIVATION; ROLES;

D O I：

10.1038/s41556-024-01360-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases. In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be potentially leveraged for therapeutic benefit for disease treatment.

引用

页码：1447 / 1457

页数：11

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