Suppressor of Cytokine Signaling 1 Haploinsufficiency A New Driver of Autoimmunity and Immunodysregulation

被引：1
作者：
Liu, Meng [1 ,2 ,3 ]
Hsu, Evan [1 ,2 ]
Du, Yan [1 ,2 ,4 ]
Lee, Pui Y. [1 ,2 ,5 ]
机构：
[1] Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA USA
[3] Guangdong Second Prov Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Rheumatol, Hangzhou, Zhejiang, Peoples R China
[5] Boston Childrens Hosp, 1 Blackfan Circle, Karp RB10th Floor, Boston, MA 02115 USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2023年 / 49卷 / 04期
关键词：
SOCS1; haploinsufficiency; Autoimmunity; Autoimmune disease; JANUS TYROSINE KINASE; SOCS PROTEINS; IFN-GAMMA; BOX; INHIBITION; INDUCTION; BINDING; FAMILY; DOMAIN;
D O I：
10.1016/j.rdc.2023.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytokines play a critical role in preparing our immune response to invading pathogens. However, a system to regulate the inflammatory effects of cytokines is equally important to prevent collateral damage. SOCS1 is a key regulator of the JAK-STAT pathway that prevents excessive signaling of interferons and other cytokines. Based on animal models and the early studies of human SOCS1 haploinsufficiency, SOCS1 serves as an essential guardian that fine-tunes the balance between immunity and autoimmunity. Future studies will help us better understand the phenotypic heterogeneity of SOCS1 haploinsufficiency and provide more effective personalized therapeutic approaches.
引用
收藏
页码：757 / 772
页数：16
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