SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

被引：21
作者：
Wang, Qi [1 ]
Xiong, Fei [1 ]
Wu, Guanhua [1 ]
Wang, Da [1 ]
Liu, Wenzheng [1 ]
Chen, Junsheng [1 ]
Qi, Yongqiang [2 ]
Wang, Bing [1 ]
Chen, Yongjun [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Biliary Pancreat Surg, Wuhan 430000, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, Sch Med,Key Lab Laparoscop Technol Zhejiang Prov, Hangzhou 310016, Peoples R China
来源：
DIAGNOSTICS | 2023年 / 13卷 / 17期
关键词：
SMAD; transforming growth factor-beta; cancer; diagnosis; treatment; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR-BETA; GASTRIC-CANCER; PROSTATE-CANCER; SKI ONCOPROTEIN; LUNG-CANCER; PROMOTES; EXPRESSION; METASTASIS; ADENOCARCINOMA;
D O I：
10.3390/diagnostics13172769
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factorfi (TGF-fi) pathway. The TGF-fi pathway is widely known for its dual role in cancer progression as both an inhibitor of tumour cell growth and an inducer of tumour metastasis. This is mainly mediated through SMAD proteins and their cofactors or regulators. SMAD proteins act as transcription factors, regulating the transcription of a wide range of genes, and their rich post-translational modifications are influenced by a variety of regulators and cofactors. The complex role, mechanisms, and important functions of SMAD proteins in tumours are the hot topics in current oncology research. In this paper, we summarize the recent progress on the effects and mechanisms of SMAD proteins on tumour development, diagnosis, treatment and prognosis, and provide clues for subsequent research on SMAD proteins in tumours.
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页数：27
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