Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis

被引:12
作者
Colombani, Julien [1 ,2 ]
Andersen, Ditte S. [1 ,2 ]
机构
[1] Univ Copenhagen, Dept Biol, Copenhagen, Denmark
[2] Univ Copenhagen, Dept Biol, Univ Pk 15,Bldg 3, DK-2100 Copenhagen, Denmark
基金
欧洲研究理事会; 欧盟地平线“2020”;
关键词
Drosophila; immunity; metabolism; TNF; tumor; TUMOR-NECROSIS-FACTOR; INSULIN-PRODUCING CELLS; ONCOGENIC RAS; FACTOR-ALPHA; GENETIC SCREEN; TNF-ALPHA; RECEPTOR; EIGER; JNK; ACTIVATION;
D O I
10.1002/1873-3468.14716
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumor necrosis factor (TNF)-a is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.
引用
收藏
页码:2416 / 2432
页数:17
相关论文
共 72 条
[1]   The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response [J].
Agrawal, Neha ;
Delanoue, Renald ;
Mauri, Alessandra ;
Basco, Davide ;
Pasco, Matthieu ;
Thorens, Bernard ;
Leopold, Pierre .
CELL METABOLISM, 2016, 23 (04) :675-684
[2]   The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies [J].
Amin, Ruhul ;
Quispe, Cristina ;
Docea, Anca Oana ;
Ydyrys, Alibek ;
Kulbayevae, Marzhan ;
Dastan, Sevgi Durna ;
Calina, Daniela ;
Sharifi-Rad, Javad .
NEUROCHEMISTRY INTERNATIONAL, 2022, 158
[3]   The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth [J].
Andersen, Ditte S. ;
Colombani, Julien ;
Palmerini, Valentina ;
Chakrabandhu, Krittalak ;
Boone, Emilie ;
Roethlisberger, Michael ;
Toggweiler, Janine ;
Basler, Konrad ;
Mapelli, Marina ;
Hueber, Anne-Odile ;
Leopold, Pierre .
NATURE, 2015, 522 (7557) :482-+
[4]   Cytokine Signaling Mediates UV-Induced Nociceptive Sensitization in Drosophila Larvae [J].
Babcock, Daniel T. ;
Landry, Christian ;
Galko, Michael J. .
CURRENT BIOLOGY, 2009, 19 (10) :799-806
[5]   The NMDA receptor regulates competition of epithelial cells in the Drosophila wing [J].
Banreti, Agnes R. ;
Meier, Pascal .
NATURE COMMUNICATIONS, 2020, 11 (01)
[6]   The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling [J].
Bergmann, A ;
Agapite, J ;
McCall, K ;
Steller, H .
CELL, 1998, 95 (03) :331-341
[7]   IDENTITY OF TUMOR NECROSIS FACTOR AND THE MACROPHAGE-SECRETED FACTOR CACHECTIN [J].
BEUTLER, B ;
GREENWALD, D ;
HULMES, JD ;
CHANG, M ;
PAN, YCE ;
MATHISON, J ;
ULEVITCH, R ;
CERAMI, A .
NATURE, 1985, 316 (6028) :552-554
[8]   ENDOGENOUS SLEEP-PROMOTING SUBSTANCES AND SLEEP REGULATION [J].
BORBELY, AA ;
TOBLER, I .
PHYSIOLOGICAL REVIEWS, 1989, 69 (02) :605-670
[9]   Secreted bacterial effectors and host-produced eiger/TNF drive death in a Salmonella-infected fruit fly [J].
Brandt, SM ;
Dionne, MS ;
Khush, RS ;
Pham, LN ;
Vigdal, TJ ;
Schneider, DS .
PLOS BIOLOGY, 2004, 2 (12) :2067-2075
[10]   scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila [J].
Brumby, AM ;
Richardson, HE .
EMBO JOURNAL, 2003, 22 (21) :5769-5779