共 72 条
Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis
被引:12
作者:

Colombani, Julien
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Biol, Copenhagen, Denmark
Univ Copenhagen, Dept Biol, Univ Pk 15,Bldg 3, DK-2100 Copenhagen, Denmark Univ Copenhagen, Dept Biol, Copenhagen, Denmark

Andersen, Ditte S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Copenhagen, Dept Biol, Copenhagen, Denmark
Univ Copenhagen, Dept Biol, Univ Pk 15,Bldg 3, DK-2100 Copenhagen, Denmark Univ Copenhagen, Dept Biol, Copenhagen, Denmark
机构:
[1] Univ Copenhagen, Dept Biol, Copenhagen, Denmark
[2] Univ Copenhagen, Dept Biol, Univ Pk 15,Bldg 3, DK-2100 Copenhagen, Denmark
基金:
欧洲研究理事会;
欧盟地平线“2020”;
关键词:
Drosophila;
immunity;
metabolism;
TNF;
tumor;
TUMOR-NECROSIS-FACTOR;
INSULIN-PRODUCING CELLS;
ONCOGENIC RAS;
FACTOR-ALPHA;
GENETIC SCREEN;
TNF-ALPHA;
RECEPTOR;
EIGER;
JNK;
ACTIVATION;
D O I:
10.1002/1873-3468.14716
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Tumor necrosis factor (TNF)-a is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.
引用
收藏
页码:2416 / 2432
页数:17
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