Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer Progression

被引：11

作者：

Ogunleye, Ayoola O. ^{[1
]}

Nimmakayala, Rama Krishna ^{[1
]}

Batra, Surinder K. ^{[1
,2
,4
]}

Ponnusamy, Moorthy P. ^{[1
,2
,3
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA

[2] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[3] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

[4] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

STEM CELLS | 2023年 / 41卷 / 05期

基金：

美国国家卫生研究院;

关键词：

pancreatic cancer; cancer stem cells; metabolism; targeting metabolic pathways; CELL FEATURES; GLUTAMINE-METABOLISM; SENSITIZES CELLS; ONCOGENIC KRAS; METAANALYSIS; GEMCITABINE; INHIBITION; HALLMARKS; GROWTH; RISK;

D O I：

10.1093/stmcls/sxad017

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases with a poor 5-year survival rate. PDAC cells rely on various metabolic pathways to fuel their unlimited proliferation and metastasis. Reprogramming glucose, fatty acid, amino acid, and nucleic acid metabolisms contributes to PDAC cell growth. Cancer stem cells are the primary cell types that play a critical role in the progression and aggressiveness of PDAC. Emerging studies indicate that the cancer stem cells in PDAC tumors are heterogeneous and show specific metabolic dependencies. In addition, understanding specific metabolic signatures and factors that regulate these metabolic alterations in the cancer stem cells of PDAC paves the way for developing novel therapeutic strategies targeting CSCs. In this review, we discuss the current understanding of PDAC metabolism by specifically exploring the metabolic dependencies of cancer stem cells. We also review the current knowledge of targeting these metabolic factors that regulate CSC maintenance and PDAC progression.

引用

页码：417 / 430

页数：14

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