Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension-2021 NHLBI Workshop Report

被引：37

作者：

Gumz, Michelle L. ^{[1
,2
]}

Shimbo, Daichi ^{[3
]}

Abdalla, Marwah ^{[4
]}

Balijepalli, Ravi C. ^{[5
]}

Benedict, Christian ^{[6
]}

Chen, Yabing ^{[7
,8
]}

Earnest, David J. ^{[9
]}

Gamble, Karen L. ^{[10
]}

Garrison, Scott R. ^{[11
]}

Gong, Ming C. ^{[12
]}

Hogenesch, John B. ^{[13
]}

Hong, Yuling ^{[5
]}

Ivy, Jessica R. ^{[14
]}

Joe, Bina ^{[15
,16
]}

Laposky, Aaron D. ^{[29
]}

Liang, Mingyu ^{[17
]}

MacLaughlin, Eric J. ^{[18
]}

Martino, Tami A. ^{[19
]}

Pollock, David M. ^{[20
]}

Redline, Susan ^{[21
]}

Rogers, Amy ^{[22
]}

Dan Rudic, R. ^{[23
]}

Schernhammer, Eva S. ^{[24
,25
]}

Stergiou, George S. ^{[26
]}

St-Onge, Marie-Pierre ^{[27
]}

Wang, Xiaoling ^{[28
]}

Wright, Jacqueline ^{[5
]}

Oh, Young S. ^{[5
]}

机构：

[1] Univ Florida, Dept Physiol & Aging, Gainesville, FL USA

[2] Univ Florida, Ctr Integrat Cardiovasc & Metab Dis, Dept Med, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA

[3] Columbia Univ, Irving Med Ctr, Columbia Hypertens Ctr, Dept Med, New York, NY USA

[4] Columbia Univ, Irving Med Ctr, Ctr Behav Cardiovasc Hlth, Dept Med, New York, NY USA

[5] NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD USA

[6] Uppsala Univ, Dept Pharmaceut Biosci, Mol Neuropharmacol, Uppsala, Sweden

[7] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL USA

[8] Birmingham VA Med Ctr, Res Dept, Birmingham, AL USA

[9] Texas A&M Univ, Dept Neurosci & Expt Therapeut, Bryan, TX USA

[10] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL USA

[11] Univ Alberta, Dept Family Med, Edmonton, AB, Canada

[12] Univ Kentucky, Dept Physiol, Lexington, KY USA

[13] Univ Cincinnati, Dept Pediat, Cincinnati, OH USA

[14] Univ Edinburgh, Univ British Heart Fdn Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Scotland

[15] Univ Toledo, Coll Med & Life Sci, Dept Physiol & Pharmacol, Toledo, OH USA

[16] Univ Toledo, Coll Med & Life Sci, Ctr Hypertens & Precis Med, Toledo, OH USA

[17] Med Coll Wisconsin, Ctr Syst Mol Med, Dept Physiol, Milwaukee, WI USA

[18] Texas Tech Univ Hlth Sci Ctr, Dept Pharm Practice, Amarillo, TX USA

[19] Univ Guelph, Ctr Cardiovasc Invest, Dept Biomed Sci, Guelph, ON, Canada

[20] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham, AL USA

[21] Harvard Med Sch, Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Boston, MA USA

[22] Univ Dundee, Div Mol & Clin Med, Dundee, Scotland

[23] Augusta Univ, Dept Pharmacol & Toxicol, Augusta, GA USA

[24] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA

[25] Harvard Med Sch, Boston, MA USA

[26] Natl & Kapodistrian Univ Athens, Hypertens Ctr, Sotiria Hosp, Dept Med 3,Sch Med,STRIDE 7, Athens, Greece

[27] Columbia Univ, Div Gen Med, Dept Med, Irving Med Ctr, New York, NY USA

[28] Augusta Univ, Georgia Prevent Inst, Dept Med, Augusta, GA USA

[29] NHLBI, Natl Ctr Sleep Disorders Res, Div Lung Dis, NIH, Bethesda, MD USA

来源：

HYPERTENSION | 2023年 / 80卷 / 03期

关键词：

circadian clock; kidney; microbiota; sleep; vasculature; NIGHT-SHIFT WORK; ISOLATED NOCTURNAL HYPERTENSION; POSITIVE AIRWAY PRESSURE; OBSTRUCTIVE SLEEP-APNEA; TARGET-ORGAN DAMAGE; CARDIOVASCULAR-DISEASE; DNA METHYLATION; GENE-EXPRESSION; RISK-FACTORS; CLOCK GENE;

D O I：

10.1161/HYPERTENSIONAHA.122.19372

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.

引用

页码：503 / 522

页数：20

共 233 条

[1] Sleep Timing, Stability, and BP in the Sueno Ancillary Study of the Hispanic Community Health Study/Study of Latinos [J].