Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation

被引：1

作者：

Otto, William R. ^{[1
,2
]}

Vora, Surabhi B. ^{[3
,4
]}

Dulek, Daniel E. ^{[5
,6
,7
,8
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH USA

[2] Univ Cincinnati, Dept Pediat, Cincinnati, OH USA

[3] Seattle Childrens Hosp, Div Infect Dis, Seattle, WA USA

[4] Univ Washington, Dept Pediat, Seattle, WA USA

[5] Monroe Carell Jr Childrens Hosp Vanderbilt, Div Pediat Infect Dis, Nashville, TN 37232 USA

[6] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[7] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Infect Dis, D-7235 Med Ctr North,1161 21st Ave S, Nashville, TN 37232 USA

[8] Monroe Carell Jr Childrens Hosp Vanderbilt, D-7235 Med Ctr North,1161 21st Ave S, Nashville, TN 37232 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2024年 / 13卷

关键词：

cell-mediated immunity; children; cytomegalovirus; hematopoietic cell transplantation; solid organ transplantation; QUANTIFERON-CMV-ASSAY; T-CELLS; ANTIVIRAL PROPHYLAXIS; INFECTION; RISK; RECIPIENTS; DISEASE; RESPONSES; REACTIVATION; RECONSTITUTION;

D O I：

10.1093/jpids/piae005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays, describe available commercial assays and strategies for their use, and summarize relevant literature regarding the use of CMI assays in transplant recipients. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays; describe available commercial assays and strategies for their use; and summarize relevant literature regarding the use of CMI assays in transplant recipients.

引用

页码：S22 / S30

页数：9

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