Highly Diastereo- and Enantioselective Synthesis of Chiral Cyclohexylphosphines by Cu-Catalyzed Phosphination-Aldol Cyclization of Ketone-Enamides

被引：1

作者：

Li, Junbao ^{[1
]}

Sun, Jinghui ^{[1
]}

Yan, Yifei ^{[1
]}

Dong, Zhuyong ^{[2
]}

Xu, Jun ^{[1
]}

Li, Wanmei ^{[1
]}

Huang, Yinhua ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China

[2] Hangzhou Create Environm Energy & Technol Co Ltd, Hangzhou 311121, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 26卷 / 01期

关键词：

ASYMMETRIC-SYNTHESIS; DIARYLPHOSPHINES; DERIVATIVES; HYDROPHOSPHINATION;

D O I：

10.1021/acs.orglett.3c03836

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly diastereo- and enantioselective phosphinative cyclization of ketone-enamides with secondary diarylphosphines enabled by copper catalysis is reported, providing a range of chiral tertiary cyclohexylphosphines bearing three contiguous stereogenic centers in high yields. This asymmetric phosphination-aldol cyclization protocol can also be extended to desymmetrization of dione-enamides to create four contiguous stereogenic centers in a highly selective manner.

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页码：210 / 214

页数：5

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