Posterior reversible encephalopathy syndrome following iatrogenic acetylcysteine overdose: a case report

被引：0
作者：
Jae, James [1 ]
Li, Yilong [2 ]
Mackenzie, Constance A. [1 ,3 ]
机构：
[1] Western Univ, Dept Med, London, ON, Canada
[2] Western Univ, Dept Microbiol & Immunol, London, ON, Canada
[3] Western Univ, St Josephs Hosp, Dept Med, 268 Grosvenor St, London, ON N6A 5A5, Canada
来源：
TOXICOLOGY COMMUNICATIONS | 2023年 / 7卷 / 01期
关键词：
Posterior reversible encephalopathy syndrome; N-acetylcysteine; acetaminophen; case report; STATUS EPILEPTICUS;
D O I：
10.1080/24734306.2023.2292879
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
We present a case of posterior reversible encephalopathy syndrome (PRES) linked to N-acetylcysteine (NAC) overdose during treatment for acetaminophen overdose. The patient presented to the emergency department following the ingestion of 455 mg/kg of acetaminophen and was administered a total of 46.2 g of NAC over 14 h in error, compared to the intended 19.8 g. She subsequently developed status epilepticus. After seizure control, brain imaging by CT and MRI showed PRES. Continuous renal replacement therapy (CRRT) was started to eliminate NAC and acetaminophen. The patient eventually recovered neurologically with improved transaminases and was free of further seizures.
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