PSMA Targeted Ligands in Imaging and Theranostics for Prostate Cancer

被引：0
作者：
Sen, Bilge [1 ]
Ozkan, Elgin [2 ]
Kucuk, Nuriye Ozlem [2 ]
机构：
[1] Ankara Univ Inst Hlth Sci, Fac Pharm, Dept Dept Analyt Chem, Ankara, Turkiye
[2] Ankara Univ Fac Med, Deparment Nucl Med, Ankara, Turkiye
来源：
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY | 2023年 / 22卷 / 04期
关键词：
PET imaging; prostate cancer; theranostics; I-AND-T; MEMBRANE ANTIGEN-EXPRESSION; RADIATION-DOSIMETRY; RADIOLIGAND THERAPY; BIOCHEMICAL RECURRENCE; PRECLINICAL EVALUATION; BONE-SCINTIGRAPHY; LYMPH-NODES; PET; BIODISTRIBUTION;
D O I：
10.4274/uob.galenos.2023.2023.8.2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer (PCa) is the second most common type of cancer in men. Compared with conventional imaging methods, prostate-specific membrane antigen (PSMA)-targeted positron emission tomography has higher accuracy and specificity for the detection and treatment of PCa. Through targeted imaging, ligands are labelled with 18F, 68Ga, or 64Cu, and the disease is staged and managed more accurately. It is also desirable to use PSMA-targeted theranostics that are labelled with either imaging radioisotopes or treatment isotopes such as 177Lu, 225Ac, 131I. Here, we summarized some of the commonly used small molecule PSMA ligands for imaging and theranostic purposes.
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页码：129 / 137
页数：9
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