A pyroptosis-related gene expression signature predicts immune microenvironment and prognosis in head and neck squamous cell carcinoma

被引：0

作者：

Zhou, Wenyuan ^{[1
]}

Feng, Mei ^{[2
]}

Qi, Fei ^{[3
]}

Qiao, Jiao ^{[4
,5
]}

Fan, Lina ^{[6
]}

Zhang, Long ^{[7
]}

Hu, Xuegang ^{[7
]}

Huang, Chunyu ^{[8
]}

机构：

[1] Peking Univ, Dept Nucl Med,Canc Hosp & Inst, Natl Med Prod Adm NMPA ,Key Lab Res & Evaluat Radi, Key Lab Carcinogenesis & Translat Res Minist Educ, Beijing 100142, Peoples R China

[2] Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China

[3] Peking Univ, Canc Hosp & Inst, Dept Lymphoma, Key Lab Carcinogenesis & Translat Res Minist Educ, Beijing 100142, Peoples R China

[4] Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China

[5] Peking Univ, Hlth Sci Ctr, Inst Med Technol, Beijing 100191, Peoples R China

[6] Fujian Med Univ, Hosp Joint Logist Support Force 900, Fuzong Clin Med Coll,PLA, Dept Stomatol, Fuzhou 350025, Fujian, Peoples R China

[7] Shenzhen Guangming Dist Peoples Hosp, Dept Stomatol, Songbai Rd 4253, Shenzhen 518107, Guangdong, Peoples R China

[8] Shenzhen Guangming Dist Peoples Hosp, Med Affairs Dept, Songbai Rd 4253, Shenzhen 518107, Guangdong, Peoples R China

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2024年 / 281卷 / 02期

关键词：

Head and neck squamous cell carcinoma; Pyroptosis; Gene expression; Immune cell infiltration; Prognosis;

D O I：

10.1007/s00405-023-08316-y

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundHead and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive malignancy with a poor prognosis. Pyroptosis triggered by gasdermins family proteins is reported vital for tumor microenvironment and cancer progression. However, pyroptosis-related gene expression and its relationship with immune infiltration and prognosis of HNSCC have not been fully defined.Material and methodsRNA-sequencing data of HNSCC patients were acquired from The Cancer Genome Atlas (TCGA) database. A pyroptosis-related gene expression signature and infiltrated immune cells were analyzed. Univariate, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression and nomogram analyses were used to construct a clinical-molecular risk model for survival prognosis.ResultsHNSCC was classified into three different molecular subtypes based on the expression information of pyroptosis-related genes. Immune cell infiltration was demonstrated to be distinct between the three subtypes. The segregation of patients into the high-risk group and low-risk group, were carried out using the signature of differential expression genes (DEGs) signature among the three molecular subtypes. The precision of this signature was corroborated by Receiver operating characteristic curve (ROC) analysis with the 3-year area under time-dependent ROC curve (AUC) reaching 0.711. The risk model was validated in another dataset from the Gene Expression Omnibus (GEO) database. Subsequently we established a clinical-molecular nomogram which combined the risk score with age and stage. The calibration plots for predicting the overall survival rate of 1-, 3-, and 5-years indicated that the nomogram performs well.ConclusionThe expression signature that encompasses pyroptosis-related genes could be used as molecular classification for HNSCC and pyroptosis might be a promising therapeutic target in HNSCC.

引用

页码：953 / 963

页数：11

共 33 条

[1]

Johnson Daniel E, 2020, Nat Rev Dis Primers, V6, P92, DOI [10.1038/s41572-020-00233-2, 10.1038/s41572-020-00224-3]

[2] Integrated analysis of immune-related gene subtype and immune index for immunotherapy in clear cell renal cell carcinoma [J].