How inflammation dictates diabetic peripheral neuropathy: An enlightening review

被引：27

作者：

Cheng, Yifan ^{[1
]}

Chen, Yinuo ^{[2
,3
]}

Li, Kezheng ^{[2
,3
]}

Liu, Shuwei ^{[3
]}

Pang, Chunyang ^{[2
]}

Gao, Lingfei ^{[2
]}

Xie, Jiali ^{[4
]}

Wenjing, L. V. ^{[5
]}

Yu, Huan ^{[6
]}

Deng, Binbin ^{[2
,3
]}

机构：

[1] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Rehabil Med,Dept Neurol, Hangzhou, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Zhejiang, Peoples R China

[4] Tongji Univ, Shanghai East Hosp, Dept Neurol, Shanghai, Peoples R China

[5] Qingdao Univ, Dept Geriatr, Affiliated Hosp, Qingdao, Shandong, Peoples R China

[6] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Pediat, Wenzhou, Peoples R China

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2024年 / 30卷 / 04期

基金：

中国国家自然科学基金;

关键词：

diabetic neuropathy; inflammatory response; metabolic changes; molecular mechanism; NF-KAPPA-B; SUBCLINICAL INFLAMMATION; INSULIN-RESISTANCE; NERVE DYSFUNCTION; SCIATIC-NERVE; MITOCHONDRIAL BIOENERGETICS; VASCULAR ENDOTHELIUM; OXIDATIVE STRESS; CELL-DEATH; POLYNEUROPATHY;

D O I：

10.1111/cns.14477

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BackgroundDiabetic peripheral neuropathy (DPN) constitutes a debilitating complication associated with diabetes. Although, the past decade has seen rapid developments in understanding the complex etiology of DPN, there are no approved therapies that can halt the development of DPN, or target the damaged nerve. Therefore, clarifying the pathogenesis of DPN and finding effective treatment are the crucial issues for the clinical management of DPN.AimsThis review is aiming to summary the current knowledge on the pathogenesis of DPN, especially the mechanism and application of inflammatory response.MethodsWe systematically summarized the latest studies on the pathogenesis and therapeutic strategies of diabetic neuropathy in PubMed.ResultsIn this seminal review, the underappreciated role of immune activation in the progression of DPN is scrutinized. Novel insights into the inflammatory regulatory mechanisms of DPN have been unearthed, illuminating potential therapeutic strategies of notable clinical significance. Additionally, a nuanced examination of DPN's complex etiology, including aberrations in glycemic control and insulin signaling pathways, is presented. Crucially, an emphasis has been placed on translating these novel understandings into tangible clinical interventions to ameliorate patient outcomes.ConclusionsThis review is distinguished by synthesizing cutting-edge mechanisms linking inflammation to DPN and identifying innovative, inflammation-targeted therapeutic approaches. Understanding the role of inflammation in diabetic peripheral neuropathy's progression.image

引用

页数：15

共 164 条

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