Thyroid Hormone-Activated Signaling Pathways are Essential for Development of Intestinal Stem Cells

被引：1
作者：
Fujimoto, Kenta [1 ]
Shibata, Yuki [1 ]
Hasebe, Takashi [1 ,2 ]
机构：
[1] Nippon Med Sch, Dept Biol, Tokyo, Japan
[2] Nippon Med Sch, Dept Biol, 1-7-1 Kyonan Cho, Musashino, Tokyo 1800023, Japan
来源：
JOURNAL OF NIPPON MEDICAL SCHOOL | 2023年 / 90卷 / 03期
关键词：
intestine; stem cells; thyroid hormone; signaling pathway; amphibian metamorphosis; ADULT EPITHELIAL DEVELOPMENT; SONIC HEDGEHOG; GENE-EXPRESSION; HIPPO PATHWAY; PROTEIN; PROLIFERATION; INHIBITION; LARVAL; TISSUE; IDENTIFICATION;
D O I：
10.1272/jnms.JNMS.2023_90-308
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Intestinal homeostasis is maintained by strict regulation of stem cell function. In mammals, several sig-naling pathways, including the formation of stem cell niches, are involved in stem cell regulation. How-ever, little is known of the molecular mechanisms involved in postembryonic maturation of the verte-brate intestine, that is, the acquisition of cell renewal systems, including stem cell development and niche formation. Using thyroid hormone (TH)-dependent intestinal remodeling during amphibian meta-morphosis as a model to study these mechanisms, we found that several signaling pathways, including the SHH/BMP4, WNT, Notch, and Hippo pathways, are regulated by TH and involved in stem cell regulation. In this review, we highlight findings regarding the role of these signaling pathways and dis-cuss potential future avenues of study. (J Nippon Med Sch 2023; 90: 246?252)
引用
收藏
页码：246 / 252
页数：7
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