New Perspectives of Taxifolin in Neurodegenerative Diseases

被引:9
作者
Yang, Rong [1 ,2 ,3 ,4 ]
Yang, Xinxing [1 ,2 ,3 ,4 ]
Zhang, Feng [1 ,2 ,3 ,4 ,5 ]
机构
[1] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi, Guizhou, Peoples R China
[2] Zunyi Med Univ, Joint Int Res Lab Ethnomed, Minist Educ, Zunyi, Guizhou, Peoples R China
[3] Zunyi Med Univ, Key Lab Basic Pharmacol Guizhou Prov, Zunyi, Guizhou, Peoples R China
[4] Zunyi Med Univ, Lab Anim Ctr, Zunyi, Guizhou, Peoples R China
[5] Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi, Guizhou, Peoples R China
基金
中国国家自然科学基金;
关键词
Taxifolin; neurodegenerative disease; neuroinflammation; oxidative stress; neuroprotection; Parkinson's disease; Alzheimer's disease; IN-VITRO; DIABETIC-NEPHROPATHY; PARKINSONS-DISEASE; MOLECULAR DOCKING; OXIDATIVE STRESS; PLANT-EXTRACTS; MOUSE MODEL; DIHYDROQUERCETIN; FLAVONOIDS; BETA;
D O I
10.2174/1570159X21666230203101107
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral amyloid angiopathy (CAA), and Huntington's disease (HD) are characterized by cognitive and motor dysfunctions and neurodegeneration. These diseases have become more severe over time and cannot be cured currently. Until now, most treatments for these diseases are only used to relieve the symptoms. Taxifolin (TAX), 3,5,7,3,4-pentahydroxy flavanone, also named dihydroquercetin, is a compound derived primarily from Douglas fir and Larix gemelini. TAX has been confirmed to exhibit various pharmacological activities, including anti-inflammation, anti-cancer, anti-virus, and regulation of oxidative stress effects. In the central nervous system, TAX has been demonstrated to inhibit A & beta; fibril formation, protect neurons and improve cerebral blood flow, cognitive ability, and dyskinesia. At present, TAX is only applied as a health additive in clinical practice. This review aimed to summarize the application of TAX in neurodegenerative diseases and the underlying neuroprotective mechanisms, such as suppressing inflammation, attenuating oxidative stress, preventing A & beta; protein formation, maintaining dopamine levels, and thus reducing neuronal loss.
引用
收藏
页码:2097 / 2109
页数:13
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