Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression

被引:1
|
作者
Unseld, Luzie Helene [1 ,2 ]
Hildebrand, Laura S. [1 ,2 ]
Putz, Florian [1 ,2 ]
Buettner-Herold, Maike [3 ]
Daniel, Christoph [3 ]
Fietkau, Rainer [1 ,2 ]
Distel, Luitpold Valentin [1 ,2 ]
机构
[1] Friedrich Alexander Univ Erlangen Nurnberg, Dept Radiat Oncol, Univ Klinikum Erlangen, Univ Str 27, D-91054 Erlangen, Germany
[2] Comprehens Canc Ctr Erlangen EMN, D-91054 Erlangen, Germany
[3] Friedrich Alexander Univ Erlangen Nurnberg, Inst Pathol, Dept Nephropathol, Univ Klinikum Erlangen, D-91054 Erlangen, Germany
关键词
malignant melanoma; cell-in-cell structures; non-professional phagocytosis; cell cannibalism; E-cadherin; metastasis; IN-CELL; DEATH PROCESS; CANNIBALISM; ENTOSIS; CANCER; LYMPHOCYTES;
D O I
10.3390/curroncol30080547
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Non-professional phagocytosis in cancer has been increasingly studied in recent decades. In malignant melanoma metastasis, cell-in-cell structures have been described as a sign of cell cannibalism. To date, only low rates of cell-in-cell structures have been described in patients with malignant melanoma. To investigate these findings further, we examined twelve primary melanoma cell lines in both adherent and suspended co-incubation for evidence of engulfment. In addition, 88 malignant melanoma biopsies and 16 healthy tissue samples were evaluated. E-cadherin levels were determined in the cell lines and tissues. All primary melanoma cell lines were capable of phagocytosis, and phagocytosis increased when cells were in suspension during co-incubation. Cell-in-cell structures were also detected in most of the tissue samples. Early T stages and increasingly advanced N and M stages have correspondingly lower rates of cell-in-cell structures. Non-professional phagocytosis was also present in normal skin tissue. Non-professional phagocytosis appears to be a ubiquitous mechanism in malignant melanoma. The absence of phagocytosis in metastases may be one reason for the high rate of metastasis in malignant melanoma.
引用
收藏
页码:7542 / 7552
页数:11
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