Diagnostic accuracy of gold nanoparticle combined with molecular method for detection of Mycobacterium tuberculosis: A systematic review and meta-analysis study

The importance of rapid detection of Mycobacterium tuberculosis (MTB) has become greater than ever. Among biosensors as a rapid test, gold nanoparticles (GNPs) can play an important role in accelerating the diagnosis of TB. This systematic review and meta-analysis study were conducted to evaluate the diagnostic accuracy of GNPs for the diagnosis of MTB. All cross sectional and case control studies as original article about rapid detection of MTB using GNPs combined with molecular methods published in PubMed, Web of Science, and Scopus databases were selected, retrieved and appraised up to September 2021. The sensitivity and specificity of GNPs in different studies ranges from 83.7% to 100% for sensitivity and from 86.6% to 100% for specificity. The highest sensitivity and specificity of GNPs combined with molecular methods was related to the LAMP method. Therefore, GNPs are a simpler, low cost and more efficient way in the clinical diagnosis of TB.