A new method to synthesize 1,2,4-oxadiazoles by using DMTMM as condensing agent

被引：4
|
作者：
Wang, Yijie [1 ]
Cheng, Xu [1 ]
Xu, Jing [1 ]
Wang, Lin [1 ]
Zhang, Shouguo [1 ]
Liu, Shuchen [1 ]
Peng, Tao [1 ]
机构：
[1] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China
来源：
TETRAHEDRON LETTERS | 2023年 / 124卷
关键词：
1; 2; 4-Oxadiazoles; Synthesis; DMTMM; INHIBITORS; DISCOVERY;
D O I：
10.1016/j.tetlet.2023.154590
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
DMTMM was used as condensing agent for synthesis of 1,2,4-oxadiazoles from corresponding carboxylic acids and amidoximes in the mixed solvent of THF and NMP. First, carboxylic acids were activated by DMTMM, and then reacted with amidoximes to convert to O-acylated amidoximes. The unusual solvent system THF-NMP successfully promoted dehydration process of O-acylated amidoximes and 1,2,4-oxa-diazoles were acquired in one-pot. This methodology provides a convenient and facile synthesis of 1,2,4-oxadiazoles with high yield.& COPY; 2023 Elsevier Ltd. All rights reserved.
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页数：4
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