The Regulatory Mechanism of Rab21 in Human Diseases

被引：1
|
作者：
Li, Xinjian [1 ]
Ni, Junjun [1 ]
Qing, Hong [1 ]
Quan, Zhenzhen [1 ]
机构：
[1] Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Rab21; GTPase family; Intracellular vesicle transportation; Neurodegenerative diseases; Cancer; Inflammation; NUCLEOTIDE EXCHANGE FACTOR; GTP-BINDING PROTEINS; SMALL GTPASES; TRAFFICKING; FAMILY; LOCALIZATION; SPECIFICITY; ACTIVATION; ADHESION; DOMAINS;
D O I：
10.1007/s12035-023-03454-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery. Maintaining the proper functions of Rab proteins is essential for normal cellular activities such as cell signaling, division, and survival. Due to their vital and irreplaceable role in regulating intracellular vesicle transportation, accumulated researches have shown that the abnormalities of Rab proteins and their effectors are closely related to human diseases. Here, this review focused on Rab21, a member of the Rab family, and introduced the structures and functions of Rab21, as well as the regulatory mechanisms of Rab21 in human diseases, including neurodegenerative diseases, cancer, and inflammation. In summary, we described in detail the role of Rab21 in human diseases and provide insights into the potential of Rab21 as a therapeutic target for diseases.
引用
收藏
页码：5944 / 5953
页数：10
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