Insight into the Clonal Lineage and Antimicrobial Resistance of Staphylococcus aureus from Vascular Access Infections before and during the COVID-19 Pandemic

被引:1
|
作者
Kao, Chih-Chen [1 ,2 ,3 ]
Lai, Chi-Hsiang [1 ]
Wong, Min-Yi [1 ]
Huang, Tsung-Yu [2 ,4 ]
Tseng, Yuan-Hsi [4 ,5 ]
Lu, Chu-Hsueh [1 ,4 ]
Lin, Chien-Chao [1 ,4 ]
Huang, Yao-Kuang [1 ,2 ,3 ]
机构
[1] Chiayi Chang Gung Mem Hosp, Div Thorac & Cardiovasc Surg, Chiayi 10020, Taiwan
[2] Chang Gung Univ, Coll Med, Taoyuan 33041, Taiwan
[3] Chiayi Hosp, Div Thorac & Cardiovasc Surg, MOHW, Chiayi 10020, Taiwan
[4] Chang Gung Mem Hosp, Dept Internal Med, Div Infect Dis, Chiayi 10020, Taiwan
[5] New Taipei Municipal Tu Cheng Hosp, Div Cardiovasc Surg, New Taipei 23656, Taiwan
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 06期
关键词
vascular access infections (VAIs); Staphylococcus aureus; antibiotic resistance; antibiotic resistance genes; multilocus sequence typing; molecular characterization; METHICILLIN-RESISTANT; MOLECULAR EPIDEMIOLOGY; UNITED-STATES; HEMODIALYSIS; EMERGENCE; CARRIAGE; CHILDREN; GENES; PCR;
D O I
10.3390/antibiotics12061070
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Patients receiving hemodialysis are at risk of vascular access infections (VAIs) and are particularly vulnerable to the opportunistic pathogen Staphylococcus aureus. Hemodialysis patients were also at increased risk of infection during the COVID-19 pandemic. Therefore, this study determined the change in the molecular and antibiotic resistance profiles of S. aureus isolates from VAIs during the pandemic compared with before. A total of 102 S. aureus isolates were collected from VAIs between November 2013 and December 2021. Before the pandemic, 69 isolates were collected, 58%, 39.1%, and 2.9% from arteriovenous grafts (AVGs), tunneled cuffed catheters (TCCs), and arteriovenous fistulas (AVFs), respectively. The prevalence of AVG and TCC isolates changed to 39.4% and 60.6%, respectively, of the 33 isolates during the pandemic. Sequence type (ST)59 was the predominant clone in TCC methicillin-resistant S. aureus (MRSA) and AVG-MRSA before the pandemic, whereas the predominant clone was ST8 in AVG-MRSA during the pandemic. ST59 carrying the ermB gene was resistant to clindamycin and erythromycin. By contrast, ST8 carrying the msrA gene was exclusively resistant to erythromycin. The ST distribution for different VAIs changed from before to during the pandemic. The change in antibiotic resistance rate for different VAIs was closely related to the distribution of specific STs.
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页数:12
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