Enriched environment can reverse chronic sleep deprivation-induced damage to cellular plasticity in the dentate gyrus of the hippocampus

被引：1
|
作者：
Xue, Shixing [1 ]
Hou, Xueyan [3 ]
Ren, Yuan [1 ]
Tang, Wei [1 ]
Wang, Wei [2 ]
机构：
[1] Dalian Univ, Dept Neurol, Affiliated Xinhua Hosp, Dalian, Liaoning, Peoples R China
[2] Dalian Univ, Dept Rehabil Med, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China
[3] Dalian Univ, Dept Med Imaging, Affiliated Xinhua Hosp, Dalian, Liaoning, Peoples R China
来源：
TRANSLATIONAL NEUROSCIENCE | 2023年 / 14卷 / 01期
关键词：
Alzheimer's disease; cellular plasticity; neurogenesis; enriched environment; chronic sleep deprivation; FAMILIAL ALZHEIMERS-DISEASE; TRANSGENIC MICE; IMPAIRED NEUROGENESIS; SYNAPTIC PLASTICITY; MOUSE MODEL; ASTROCYTES; NEURONS; GLIA;
D O I：
10.1515/tnsci-2022-0280
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective ? We studied whether enriched environment (EE), a classic epigenetics paradigm, can prevent cellular plasticity damage caused by chronic sleep deprivation (SD).Methods ? We performed SD in mice by a modified multi-platform method (MMPM). Mice in the SD group were deprived of sleep for 18 h a day. In addition, half of the mice in the chronic SD group were exposed to EE stimuli for 6 h per day. Immunostaining analyzed neuro-genesis and neural progenitor cell-differentiated pheno-types in the hippocampal dentate gyrus (DG) region.Result ? At 13 weeks, compared with the control group, SD severely impaired the proliferation and differentiation of neural stem cells, and EE completely reversed the pro-cess. SD can induce gliosis in the mouse hippocampus, and EE can delay the process. Conclusion: ? Our results suggest that chronic SD may damage the neurogenesis in the DG of the hippocampus. However, enrichment stimulation can reverse the proces-sing by promoting neuronal repair related to neuronal plasticity.
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页数：10
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