A New, Ecological and Stability-indicating Method by HPLC for the Quantification of Moxifloxacin in Tablets

被引：3

作者：

da Silva, Thaisa Alves Celedonio ^{[1
]}

da Silva Junior, Joao Roberto ^{[1
]}

Kogawa, Ana Carolina ^{[1
]}

机构：

[1] Univ Fed Goias, Fac Farm, Dept Pharm, Lab Controle Qualidade, Rua 240,S-N,Setor Leste Univ, BR-74605170 Goiania, GO, Brazil

来源：

CURRENT GREEN CHEMISTRY | 2023年 / 10卷 / 02期

关键词：

HPLC; green analytical chemistry; method validation; tablets; fluoroquinolone; moxifloxacin; GREEN;

D O I：

10.2174/2213346110666230331085433

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33 degrees C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin(-1), injection volume of 5 mu L, and detection at 290 nm was used. Methods: The method was linear (2-12 mu gmL(-1)), selective, accurate (100.86%), precise (RSD<2%), and robust. Results: The retention time for moxifloxacin in tablets was approximately 4.4 minutes. Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.

引用

页码：165 / 173

页数：9

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