The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology

被引：0
作者：
Jahandideh, Mina [1 ]
Ebrahimi, Erfan [2 ]
Farzaei, Mohammad Hosein [3 ]
Barzegari, Ebrahim [1 ]
机构：
[1] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran
[3] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran
来源：
BRAIN AND BEHAVIOR | 2023年 / 13卷 / 10期
关键词：
bipolar disorder; hippocampal gyrus; lithium; pharmacogenomics; RNA-sequence analysis; BIPOLAR DISORDER; PROTEIN; MECHANISMS; GENE;
D O I：
10.1002/brb3.3215
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
ObjectiveTo identify the genomics underpinning the increased volume of the hippocampus after long-term administration of lithium (Li) in bipolar disorder patients, hypothesizing the possible contribution of cell growth and differentiation pathways to this complication. MethodsRNA-seq profiles of four samples of hippocampal progenitor cells chronically treated with a high dose of Li and three samples chronically treated with the therapeutic dose were retrieved from NCBI-GEO. The raw data underwent filtration, quality control, expression fold change, adjusted significance, functional enrichment, and pharmacogenomic analyses. ResultsCCND1, LOXL2, and PRNP were identified as the genes involved in the drug response and the chronic effects of Li in the hippocampal cells. GSK-3 & beta; was also a hub in the pharmacogenomic network of Li. In addition, ZMPSTE24 and DHX35 were identified as the important genes in lithium therapy. ConclusionsAs shown by gene ontology results, these findings conclude that lithium may increase the size of the hippocampus in bipolar patients by stimulating the generation of new neurons and promoting their differentiation into neuroblasts, neurons, or microglia.
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