Multiple sclerosis and ulcerative colitis: A systematic review and meta-analysis

被引:3
作者
Nabizadeh, Fardin [2 ]
Azizi, Ali [3 ]
Hejrati, Lina [4 ]
Mousavi, Maryam [4 ]
Mehranzadeh, Ali [3 ]
Badihian, Shervin [5 ]
Tavallaei, Mohammad Javad [4 ]
Rahmanian, Vahid [6 ]
Amiri, Bahareh Shateri [1 ]
Rafiei-Sefiddashti, Raheleh [7 ]
Hejrati, Alireza [8 ]
机构
[1] Iran Univ Med Sci, Hazrat e Rasool Gen Hosp, Sch Med, Dept Internal Med, Tehran, Iran
[2] Universal Sci Educ & Res Network, NRG, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[4] Iran Univ Med Sci, Sch Med, Tehran, Iran
[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD USA
[6] Torbat Jam Fac Med Sci, Dept Publ Hlth, Torbat Jam, Iran
[7] Iran Univ Med Sci, Sch Med, Dept Parasitol & Mycol, Tehran, Iran
[8] Iran Univ Med Sci, Sch Med, Dept Internal Med, Tehran, Iran
关键词
Ulcerative colitis; multiple sclerosis; demyelination; systematic review; comorbidity; INFLAMMATORY BOWEL DISEASES; PATHOGENESIS; PREVALENCE; CELLS;
D O I
10.1177/20552173231186516
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BackgroundComorbidity is a current area of interest in multiple sclerosis (MS) and is essential for multidisciplinary management. Although recent studies suggest that patients with MS have an elevated risk of developing inflammatory bowel diseases (IBD), this systematic review and meta-analysis aimed to estimate the overall risk of developing ulcerative colitis (UC), specifically in patients with MS. MethodsIn 2021, a comprehensive literature search was performed on PubMed, Scopus, Embase, and Web of Science to identify studies investigating the association between UC and MS. The selected papers were utilized to estimate the associations, risk ratios (RRs), and a 95% confidence interval (CI). ResultsThe analysis revealed a slightly elevated risk of UC incidence in patients with MS compared to controls, but this finding was not statistically significant (RR: 1.27 [95% CI: 0.96-1.67]). In contrast, the study found that patients with UC have a significantly higher risk of developing MS than controls (RR: 1.66 [95% CI: 1.15-2.40]). ConclusionOur findings highlight that the presence of UC increases the risk of developing MS by more than 50%, whereas the presence of MS does not increase the risk of UC occurrence. These results underscore the importance of considering the potential development of UC in the clinical management and early diagnosis of patients with MS, as it may contribute to better therapeutic outcomes.
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页数:10
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