Root mean square of successive differences is not a valid measure of parasympathetic reactivity during slow deep breathing

被引:8
作者
Ali, M. Khawar [1 ,2 ]
Liu, Lijun [1 ]
Hussain, Amer [1 ]
Zheng, Difei [1 ,3 ]
Alam, Marzia [1 ]
Chen, Ji-Hong [1 ,4 ]
Huizinga, Jan D. [1 ,2 ,4 ]
机构
[1] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Med, Hamilton, ON, Canada
[2] McMaster Univ, McMaster Sch Biomed Engn, Dept Engn, Hamilton, ON, Canada
[3] McMaster Univ, Fac Hlth Sci, Honours Biol Pharmacol Coop Program, Hamilton, ON, Canada
[4] McMaster Univ, Dept Med, Div Gastroenterol, Hamilton, ON, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
autonomic nervous system; deep breathing; heart rate variability; RMSSD; RSA; HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; NORMAL RANGE; DETERMINANTS; FAILURE; TONE;
D O I
10.1152/ajpregu.00272.2022
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Deep breathing exercises are the second most used complementary health approach in the United States. Two heart rate variability (HRV) parameters, the root mean square of successive differences (RMSSD) and the respiratory sinus arrhythmia (RSA), are used to assess parasympathetic reactivity to deep breathing, but they are often not in agreement. Our purpose was to determine the cause of the disagreement. We investigated HRV parameters in 38 subjects during baseline, deep breathing, and recovery. Here we show that RMSSD as a measure of parasympathetic reactivity is unreliable; it does not reflect the increase in HRV during deep breathing as determined by RSA. We observed a decrease in RMSSD values despite a marked increase in HRV as determined by RSA and the standard deviation of normal heartbeat interval (SDNN) in healthy subjects and patients with functional bowel disorders. We show that RSA captures all aspects of HRV, whereas successive differences in heart rate intervals are only a small part of HRV, with decreasing variability during deep breathing in most subjects. We present a new measure of calculating RSA during deep breathing that may become an essential tool for researchers and clinicians. We also provide a unique visualization of the increased heart rate variability during deep breathing. Hence, RMSSD cannot be used to assess parasympathetic reactivity during deep breathing; using RSA is recommended. The use of RMSSD in previous influential studies may have led to erroneous conclusions about parasympathetic reactivity during deep breathing. Its continued use may undervalue the effects of the autonomic nervous system in slow deep breathing.
引用
收藏
页码:R446 / R456
页数:11
相关论文
共 33 条
[1]   Optimizing Autonomic Function Analysis via Heart Rate Variability Associated With Motor Activity of the Human Colon [J].
Ali, M. Khawar ;
Liu, Lijun ;
Chen, Ji-Hong ;
Huizinga, Jan D. .
FRONTIERS IN PHYSIOLOGY, 2021, 12
[2]  
Altini M., 2022, ULTIMATE GUIDE HEART
[3]   Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis [J].
Benichou, Thomas ;
Pereira, Bruno ;
Mermillod, Martial ;
Tauveron, Igor ;
Pfabigan, Daniela ;
Maqdasy, Salwan ;
Dutheil, Frederic .
PLOS ONE, 2018, 13 (04)
[4]   Acute effects on cardiovascular oscillations during controlled slow yogic breathing [J].
Bhagat, Om Lata ;
Kharya, Chhaya ;
Jaryal, Ashok ;
Deepak, Kishore Kumar .
INDIAN JOURNAL OF MEDICAL RESEARCH, 2017, 145 :503-512
[5]  
Colombo J., 2015, Clinical autonomic dysfunction
[6]   Learn to breathe, breathe to learn? No evidence for effects of slow deep breathing at a 0.1 Hz frequency on reversal learning [J].
D'Agostini, Martina ;
Claes, Nathalie ;
Franssen, Mathijs ;
von Leupoldt, Andreas ;
Van Diest, Ilse .
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2022, 174 :92-107
[7]   The human respiratory gate [J].
Eckberg, DL .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 548 (02) :339-352
[8]   ASSESSMENT OF PARASYMPATHETIC CONTROL OF HEART-RATE BY A NONINVASIVE METHOD [J].
FOUAD, FM ;
TARAZI, RC ;
FERRARIO, CM ;
FIGHALY, S ;
ALICANDRI, C .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (06) :H838-H842
[9]   Effect of slow, deep breathing on visceral pain perception and its underlying psychophysiological mechanisms [J].
Gholamrezaei, Ali ;
Van Diest, Ilse ;
Aziz, Qasim ;
Pauwels, Ans ;
Tack, Jan ;
Vlaeyen, Johan W. S. ;
Van Oudenhove, Lukas .
NEUROGASTROENTEROLOGY AND MOTILITY, 2022, 34 (04)
[10]   Toward understanding respiratory sinus arrhythmia: Relations to cardiac vagal tone, evolution and biobehavioral functions [J].
Grossman, Paul ;
Taylor, Edwin W. .
BIOLOGICAL PSYCHOLOGY, 2007, 74 (02) :263-285