Changes in the management of chronic thromboembolic pulmonary hypertension over a 10-year period, in a French expert regional competence centre

被引：1

作者：

Provosta, Mathilde ^{[1
]}

Mornexa, Jean-Francois ^{[1
,2
,3
]}

Nassera, Mouhamad ^{[1
,2
]}

Zeghmara, Sabrina ^{[1
]}

Tracleta, Julie ^{[1
,2
]}

Ahmada, Kais ^{[1
,2
]}

Lestellea, Francois ^{[1
,2
]}

Choura, Ali ^{[1
]}

Dieslera, Remi ^{[1
]}

Cottina, Vincent ^{[1
,2
,3
]}

Turquiera, Segolene ^{[1
,4
]}

机构：

[1] Hop Louis Pradel, Hosp Civils Lyon, Ctr Competences Hypertens Plum Pulmo Tens, Serv Pneumol, Lyon, France

[2] Hop Louis Pradel, Hosp Civils Lyon, Ctr Reference Coordonnateur Malad Plum Rares Respi, Serv Pneumol, Lyon, France

[3] Univ Lyon 1, Univ Lyon, INRAE, EPHE,UMR754,IVPC, F-69007 Lyon, France

[4] Hosp Civils Lyon, Hop Louis Pradel, Competence Ctr Severe Pulm Hypertens, 28 Ave Doyen Lepine, F-69500 Bron, France

来源：

RESPIRATORY MEDICINE AND RESEARCH | 2023年 / 84卷

关键词：

Pulmonary hypertension; Thrombosis; Pulmonary endarterectomy; Angioplasty; Survival; ANGIOPLASTY;

D O I：

10.1016/j.resmer.2023.101021

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Over the last few years, the advent of balloon pulmonary angioplasty (BPA) had led to changes in the man-agement of chronic thromboembolic pulmonary hypertension (CTEPH). We reviewed data from 98 CTEPH patients diagnosed during the last decade in a pulmonary hypertension (PH) expert centre. The management modalities of 2 periods (Period A: 2011-15 and Period B: 2016-20) were compared. Age (period A: 72 [58 -80] years; period B: 69 [62-79] years), clinical (New York Heart Association (NYHA) functional class III-IV: 25/41, 61% vs 39/57, 68%), and hemodynamic assessments (pulmonary vascular resistance: 7.5 [6.2-8.7] WU vs 8.0 [6.0-10.2] WU) at baseline were not significantly different. Pulmonary endarterectomy was performed in less than one third of patients (12, 29.3% vs 15, 26.3%). For patients not eligible for surgery, medical therapy was mostly prescribed alone during period A (medical therapy alone, patients diagnosed in period A: 61% vs in period B: 17.5%) while it was associated with BPA during period B (medical therapy + BPA, 12% vs 61.4%). The 5-year survival rate was excellent for patients who underwent surgery (96.3%) or BPA (95.2%), but was only 42.1% for patients under oral medication only (p < 0.0001). Patients diagnosed with CTEPH who cannot be operated should undergo BPA. The survival rate after BPA is as good as after surgery and significantly bet-ter than that of oral medication only.& COPY; 2023 SPLF and Elsevier Masson SAS. All rights reserved.

引用

页数：5