Production of Reactive Oxygen Species by Genetically Encoded Photosensitizers 4D5scFv-miniSOG and DARPin-miniSOG in Living Cells

被引：1

作者：

Proshkina, G. M. ^{[1
]}

Shramova, E. I. ^{[1
]}

Deyev, S. M. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[2] Sechenov Univ, Sechenov First Moscow State Med Univ, Minist Hlth Russian Federat, Moscow 119991, Russia

来源：

BIOLOGICHESKIE MEMBRANY | 2023年 / 40卷 / 01期

关键词：

reactive oxygen species; genetically encoded photosensitizers; photodynamic therapy; BREAST-CANCER; EXPRESSION; THERAPY;

D O I：

10.31857/S0233475523010073

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Currently, experimental oncology is developing approaches based on the development of targeted photosensitizers that can be delivered specifically to a tumor of a certain molecular profile. This work is devoted to the study of the generation of reactive oxygen species by photosensitizers of protein nature 4D5scFv-miniSOG and DARPin-miniSOG, specific to the oncomarker HER2. It was found that despite the presence of the same phototoxic module in their composition, these photosensitizers are characterized by different levels of ROS production, which may be explained by the different rate of receptor-mediated internalization of 4D5scFv-miniSOG and DARPin-miniSOG.

引用

页码：61 / 65

页数：5

共 5 条

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[5] 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells
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