Sarcomatoid malignant pleural mesothelioma associated with anti-Ma2-related paraneoplastic neurological syndrome: A case report

被引：0
|
作者：
Tada, Akio [1 ]
Kuribayashi, Kozo [1 ]
Kitajima, Kazuhiro [2 ]
Nakamura, Akifumi [3 ]
Yuki, Michiko [4 ]
Kanemura, Shingo [1 ]
Shibata, Eisuke [1 ]
Negi, Yoshiki [1 ]
Ishigaki, Hirotoshi [5 ]
Nakajima, Yasuhiro [1 ]
Takahashi, Ryo [1 ]
Yokoi, Takashi [1 ]
Minami, Toshiyuki [1 ]
Kijima, Takashi [1 ]
机构：
[1] Hyogo Med Univ, Dept Resp Med & Hematol, Sch Med, 1-1 Mukogawa cho, Nishinomiya, Hyogo 6638501, Japan
[2] Hyogo Med Univ, Dept Radiol, Sch Med, Nishinomiya, Hyogo, Japan
[3] Hyogo Med Univ, Div Thorac Surg, Sch Med, Nishinomiya, Hyogo, Japan
[4] Hyogo Med Univ, Dept Mol Pathol, Sch Med, Nishinomiya, Hyogo, Japan
[5] Asahi Univ Hosp, Dept Respirol, Gifu, Japan
来源：
CURRENT PROBLEMS IN CANCER: CASE REPORTS | 2023年 / 11卷
关键词：
Anti-Ma2; antibodies; Cerebellar degeneration; Immunoglobulin therapy; Paraneoplastic syndrome; Sarcomatoid mesothelioma;
D O I：
10.1016/j.cpccr.2023.100244
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Paraneoplastic neurological syndrome (PNS) is rarely associated with malignant pleural mesothelioma (MPM). We report the first case of sarcomatoid mesothelioma in a 63-year-old female diagnosed with cerebellar degeneration in January 2018. Systemic examination showed right pleura thickening. The pleural biopsy of the mass revealed a sarcomatoid MPM cT3N0M0. In February 2018, anti-Ma2 antibody positivity indicated PNS complicated with MPM. First, cisplatin (75 mg/m2) + pemetrexed (500 mg/m2) chemotherapy was given. For PNS, steroid pulse therapy and high-dose immunoglobulin therapy were administered. MPM may cause anti-Ma2 antibody-related PNS. Early diagnosis and starting anticancer treatment and immunotherapy are critical.
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