Visible-Light-Promoted Metal-Free 3-Arylation of 2-Aryl-2H-indazoles with Triarylsulfonium Salts

被引：11

作者：

Shi, Anzai ^{[1
]}

Xiang, Panjie ^{[1
]}

Wu, Yanxuan ^{[1
]}

Ge, Chang ^{[1
]}

Liu, Yan ^{[3
]}

Sun, Kai ^{[1
,2
]}

Yu, Bing ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Kexue Rd 100, Zhengzhou 450001, Peoples R China

[2] Huaihua Univ, Coll Chem & Mat Engn, Huaihua 418008, Peoples R China

[3] Henan Univ Engn, Henan Int Joint Lab Rare Earth Composite Mat, Coll Mat Engn, Zhengzhou 451191, Peoples R China

来源：

SYNLETT | 2023年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

visible light; radical; metal-free; arylation; 2-aryl-2H-indazoles; triarylsulfonium salts; 2H-INDAZOLE DERIVATIVES; SULFONYLATION; ACTIVATION; INDAZOLES; ARYLATION; 4CZIPN;

D O I：

10.1055/a-1938-9550

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach for the photosynthesis of various arylated 2-aryl-2H-indazoles (38 examples) in moderate to good yields (up to 87% yield) under mild conditions was developed by employing 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) as an inexpensive photocatalyst. This protocol features wide substrate scope, good functional group tolerance, and operational simplicity. In addition, the strategy was successfully applied to the late-stage modification of drug molecules, and the meaningful introduction of complex drugs to the skeleton of 2H-Indazole was achieved for the first time.

引用

页码：457 / 464

页数：8

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