Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis

被引：7
作者：
Subramaniam, Mohana Devi [1 ]
Janaki, P. Aishwarya [1 ]
Kumar, B. Abishek [1 ]
Gopalarethinam, Janani [1 ]
Nair, Aswathy P. [1 ]
Mahalaxmi, I. [2 ]
Vellingiri, Balachandar [3 ]
机构：
[1] Sankara Nethralaya, Vis Res Fdn, SN ONGC Dept Genet & Mol Biol, Chennai 600006, Tamil Nadu, India
[2] Karpagam Acad Higher Educ Deemed Univ, Dept Microbiol, Coimbatore 641021, India
[3] Cent Univ Punjab, Sch Basic Sci, Dept Zool, Bathinda, India
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 08期
关键词：
Parkinson's disease (PD); Dopamine depletion; Retinal changes; Non-invasive biomarker; UBIQUITIN-PROTEASOME SYSTEM; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; LAYER THICKNESS; DOPAMINE; NEURODEGENERATION; MUTATIONS; RESPONSES; RELEASE; NEURONS;
D O I：
10.1007/s10571-023-01419-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Parkinson's disease (PD) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) which leads to the depletion of dopamine in the body. The lack of dopamine is mainly due to aggregation of misfolded alpha-synuclein which causes motor impairment in PD. Dopamine is also required for normal retinal function and the light-dark vision cycle. Misfolded alpha-synuclein present in inner retinal layers causes vision-associated problems in PD patients. Hence, individuals with PD also experience structural and functional changes in the retina. Mutation in LRRK2, PARK2, PARK7, PINK1, or SNCA genes and mitochondria dysfunction also play a role in the pathophysiology of PD. In this review, we discussed the different etiologies which lead to PD and future prospects of employing non-invasive techniques and retinal changes to diagnose the onset of PD earlier. [GRAPHICS]
引用
收藏
页码：3983 / 3996
页数：14
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