The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control

被引：18

作者：

Deng, Jinhai ^{[1
,2
]}

Pan, Teng ^{[3
]}

Liu, Zaoqu ^{[4
]}

McCarthy, Caitlin ^{[1
]}

Vicencio, Jose M. ^{[1
]}

Cao, Lulu ^{[5
,6
]}

Alfano, Giovanna ^{[1
]}

Suwaidan, Ali Abdulnabi ^{[1
]}

Yin, Mingzhu ^{[2
]}

Beatson, Richard ^{[1
,7
]}

Ng, Tony ^{[1
,8
,9
]}

机构：

[1] Kings Coll London, Sch Canc & Pharmaceut Sci, Richard Dimbleby Lab Canc Res, London, England

[2] Chongqing Univ, Clin Res Ctr CRC, Clin Pathol Ctr CPC, Three Gorges Hosp, Chongqing, Peoples R China

[3] Shantou Univ, Longgang Dist Matern & Child Healthcare Hosp Shenz, Longgang Matern & Child Inst, Med Coll, Shenzhen 518172, Peoples R China

[4] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou, Peoples R China

[5] Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China

[6] Beijing Key Lab Rheumatism Mech & Immune Diag BZ01, Beijing, Peoples R China

[7] Univ Coll London UCL, Ctr Inflammat & Tissue Repair, Div Med, UCL Resp, Rayne 9 Bldg, London WC1E 6JF, England

[8] UCL, UCL Canc Inst, London, England

[9] Canc Res UK City London Ctr, London, England

来源：

BRITISH JOURNAL OF CANCER | 2023年 / 129卷 / 12期

关键词：

THIOREDOXIN-INTERACTING-PROTEIN; UP-REGULATED PROTEIN-1; GENE-EXPRESSION; OXIDATIVE STRESS; D-ALLOSE; HEPATOCELLULAR-CARCINOMA; LUNG ADENOCARCINOMA; NLRP3; INFLAMMASOME; DENDRITIC CELLS; SMALL-MOLECULE;

D O I：

10.1038/s41416-023-02442-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from regulating glucose and lipid metabolism, to cell cycle arrest and inflammation. Its expression is increased by stressors commonly found in neoplastic cells and the wider tumor microenvironment (TME), and, as such, TXNIP has been extensively studied in cancers. In this review, we evaluate the current literature regarding the regulation and the function of TXNIP, highlighting its emerging role in modulating signaling between different cell types within the TME. We then assess current and future translational opportunities and the associated challenges in this area. An improved understanding of the functions and mechanisms of TXNIP in cancers may enhance its suitability as a therapeutic target.

引用

页码：1877 / 1892

页数：16

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