Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics

被引：15

作者：

Wiest, Christoph ^{[1
]}

He, Shenghong ^{[1
]}

Duchet, Benoit ^{[1
]}

Pogosyan, Alek ^{[1
]}

Benjaber, Moaad ^{[1
]}

Denison, Timothy ^{[1
]}

Hasegawa, Harutomo ^{[2
]}

Ashkan, Keyoumars ^{[2
]}

Baig, Fahd ^{[1
,3
]}

Bertaina, Ilaria ^{[3
,4
]}

Morgante, Francesca ^{[3
]}

Pereira, Erlick A. ^{[3
]}

Torrecillos, Flavie ^{[1
]}

Tan, Huiling ^{[1
]}

机构：

[1] Univ Oxford, Med Res Council Brain Network Dynam Unit, Nuffield Dept Clin Neurosci, Oxford, England

[2] Kings Coll Hosp London, Dept Neurosurg, Denmark Hill, London, England

[3] St Georges Univ London, Mol & Clin Sci Inst, Neurosci Res Ctr, London, England

[4] Ente Osped Cantonale, Neuroctr Southern Switzerland, Neurol Dept, Lugano, Switzerland

来源：

NEUROBIOLOGY OF DISEASE | 2023年 / 178卷

基金：

英国医学研究理事会;

关键词：

Parkinson?s disease; Deep brain stimulation; Evoked resonant neural activity; Adaptive DBS; Local field potentials; Subthalamic nucleus; DEEP BRAIN-STIMULATION; PARKINSONS-DISEASE; NUCLEUS;

D O I：

10.1016/j.nbd.2023.106019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field po-tentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective in-tensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS.

引用

页数：15

共 34 条

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