Novel identification of t(14;18)(q32;q21)/IGH::MALT1 in chronic lymphocytic leukaemia

被引：0

作者：

Kumar, Jyoti ^{[1
,2
,5
]}

Ewalt, Mark D. ^{[1
,2
]}

Zhang, Yanming ^{[3
]}

Yao, Jinjuan ^{[2
]}

Thompson, Meghan C. ^{[4
]}

Dogan, Ahmet ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, Hematopathol Serv, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, Diagnost Mol Pathol Serv, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, Cytogenet Lab, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10065 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, 1275 York Ave,C-563E, New York, NY 10065 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 02期

关键词：

chronic lymphocytic leukaemia; CLL; IGH::MALT1; t(14; 18);

D O I：

10.1111/bjh.19235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic lymphocytic leukaemia (CLL) is a clonal B-cell malignancy and remains a chronic disease despite improvements in clinical outcomes since the use of targeted therapies. Both clinical and biological parameters are important for determining prognosis. Unlike other mature B-cell lymphomas, translocations involving the immunoglobulin heavy chain (IGH) locus are uncommon in CLL. There have been few case reports of CLL harbouring t(14;18)/IGH::BCL2 and t(14;19)/IGH::BCL3. Here we describe the first two cases of patients with CLL with documented t(14;18)(q32;q21)/IGH::MALT1. Both cases in this report were associated with lower-risk biological parameters. Thus, FISH testing for MALT1 in cases with unknown IGH translocation partners in the setting of CLL should be implemented in clinical practice to better define such cases.

引用

页码：561 / 565

页数：5

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