Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease

被引:6
作者
Das, Sabya Sachi [1 ,2 ]
Jha, Niraj Kumar [3 ,4 ,5 ]
Jha, Saurabh Kumar [3 ,4 ,6 ]
Verma, Priya Ranjan Prasad [1 ]
Ashraf, Ghulam Md [7 ,8 ]
Singh, Sandeep Kumar [1 ]
机构
[1] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India
[2] DIT Univ, Sch Pharmaceut & Populat Hlth Informat, Dehra Dun 248009, India
[3] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, India
[4] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India
[5] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, Punjab, India
[6] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, Punjab, India
[7] Univ Sharjah, Coll Hlth Sci, Dept Med Lab Sci, Sharjah 27272, U Arab Emirates
[8] Univ Sharjah, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates
关键词
Quercetin; Parkinson's disease; neuroprotective effects; alpha-synuclein protein; alpha-synuclein-associated molecular hallmarks; antioxidant; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE; GLUTATHIONE;
D O I
10.2174/1570159X21666221221092250
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Quercetin, a natural antioxidant, exhibits potential neuroprotective effects by efficiently downregulating alpha-synuclein protein aggregation and associated neurological hallmarks, responsible for the progression of Parkinson's Disease.
引用
收藏
页码:1464 / 1466
页数:3
相关论文
共 20 条
[1]   Application of quercetin in neurological disorders: from nutrition to nanomedicine [J].
Amanzadeh, Elnaz ;
Esmaeili, Abolghasem ;
Rahgozar, Soheila ;
Nourbakhshnia, Maryam .
REVIEWS IN THE NEUROSCIENCES, 2019, 30 (05) :555-572
[2]   Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity [J].
Calabrese, Vittorio ;
Mancuso, Cesare ;
Calvani, Menotti ;
Rizzarelli, Enrico ;
Butterfield, D. Allan ;
Stella, Anna Maria Giuffrida .
NATURE REVIEWS NEUROSCIENCE, 2007, 8 (10) :766-775
[3]   Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders [J].
Calabrese, Vittorio ;
Cornelius, Carolin ;
Dinkova-Kostova, Albena T. ;
Calabrese, Edward J. ;
Mattson, Mark P. .
ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (11) :1763-1811
[4]  
Das S. S., 2020, Nanomedicine for Bioactives: Healthcare applications, P259, DOI DOI 10.1007/978-981-15-1664-1_9
[5]   Food-Grade Quercetin-Loaded Nanoemulsion Ameliorates Effects Associated with Parkinson's Disease and Cancer: Studies Employing a Transgenic C. elegans Model and Human Cancer Cell Lines [J].
Das, Sabya Sachi ;
Sarkar, Arunabh ;
Chabattula, Siva Chander ;
Verma, Priya Ranjan Prasad ;
Nazir, Aamir ;
Gupta, Piyush Kumar ;
Ruokolainen, Janne ;
Kesari, Kavindra Kumar ;
Singh, Sandeep Kumar .
ANTIOXIDANTS, 2022, 11 (07)
[6]   Elevation of mitochondrial glutathione by γ-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress [J].
Drake, J ;
Sultana, R ;
Aksenova, M ;
Calabrese, V ;
Butterfield, DA .
JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (06) :917-927
[7]   Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies [J].
Henriquez, Gabriela ;
Gomez, Alejandra ;
Guerrero, Erick ;
Narayan, Mahesh .
ACS CHEMICAL NEUROSCIENCE, 2020, 11 (19) :2915-2934
[8]   Neuropharmacological Effects of Quercetin: A Literature-Based Review [J].
Islam, Md. Shahazul ;
Quispe, Cristina ;
Hossain, Rajib ;
Islam, Muhammad Torequl ;
Al-Harrasi, Ahmed ;
Al-Rawahi, Ahmed ;
Martorell, Miquel ;
Mamurova, Assem ;
Seilkhan, Ainur ;
Altybaeva, Nazgul ;
Abdullayeva, Bagila ;
Docea, Anca Oana ;
Calina, Daniela ;
Sharifi-Rad, Javad .
FRONTIERS IN PHARMACOLOGY, 2021, 12
[9]   Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain [J].
Khan, Amjad ;
Ali, Tahir ;
Rehman, Shafiq Ur ;
Khan, Muhammad Sohail ;
Alam, Sayed Ibrar ;
Ikram, Muhammad ;
Muhammad, Tahir ;
Saeed, Kamran ;
Badshah, Haroon ;
Kim, Myeong Ok .
FRONTIERS IN PHARMACOLOGY, 2018, 9 :1-16
[10]   Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species [J].
Mancuso, Cesare ;
Pani, Giovambattista ;
Calabrese, Vittorio .
REDOX REPORT, 2006, 11 (05) :207-213