Mechanism and regulation of mitophagy in nonalcoholic fatty liver disease (NAFLD): A mini-review

被引：17

作者：

Zhu, Lihui ^{[1
]}

Wu, Xiao ^{[2
,3
]}

Liao, Rongrong ^{[1
,3
]}

机构：

[1] Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, Shanghai 201106, Peoples R China

[2] Shanghai Acad Agr Sci, Biotechnol Res Inst, Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China

[3] 2901 Beidi Rd, Shanghai 201106, Peoples R China

来源：

LIFE SCIENCES | 2023年 / 312卷

关键词：

Autophagy; Metabolism; Traditional Chinese medicine; Fatty liver disease; Lipid; HEPATIC STEATOSIS; DIRECT PHOSPHORYLATION; STRUCTURAL BASIS; OBESE MICE; AMPK; AUTOPHAGY; PARKIN; FUNDC1; METABOLISM; MITOCHONDRIA;

D O I：

10.1016/j.lfs.2022.121162

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mitochondrial dysfunction has been hypothesized to play a central role in the pathobiology of nonalcoholic fatty liver disease (NAFLD). Thus, maintenance of mitochondria homeostasis and function is important for NAFLD treatment. Mitophagy, a process that selectively clears damaged or dysfunctional mitochondria through auto-phagic machinery, is beneficial for mitochondrial homeostasis. Notably, strategies that regulate mitophagy exert beneficial effects in preclinical experiments. Traditional Chinese medicine (TCM) is a natural product including active ingredients, extracts, and has great potential in the prevention and treatment of liver diseases. Given the importance of mitophagy, this review summarizes mitophagy-related pathways and the latest findings on the regulation of mitophagy in NAFLD. We also highlight the potential of TCM targeting mitophagy for the treatment

引用

页数：8

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