The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice

被引：4

作者：

Jesus Rodriguez-Sojo, Maria ^{[1
,2
]}

Jesus Ruiz-Malagon, Antonio ^{[1
,2
]}

Hidalgo-Garcia, Laura ^{[1
,2
]}

Alberto Molina-Tijeras, Jose ^{[1
,2
]}

Diez-Echave, Patricia ^{[1
,2
]}

Lopez-Escanez, Laura ^{[1
,2
]}

Rosati, Lucrezia ^{[3
]}

Gonzalez-Lozano, Elena ^{[1
]}

Cenis-Cifuentes, Laura ^{[4
]}

Garcia-Garcia, Jorge ^{[1
]}

Garcia, Federico ^{[2
,5
,6
]}

Robles-Vera, Inaki ^{[1
,2
]}

Romero, Miguel ^{[1
,2
,7
]}

Duarte, Juan ^{[1
,2
,7
]}

Luis Cenis, Jose ^{[8
]}

Abel Lozano-Perez, Antonio ^{[8
,9
]}

Galvez, Julio ^{[1
,2
,10
]}

Elena Rodriguez-Cabezas, Maria ^{[1
,2
]}

Rodriguez-Nogales, Alba ^{[1
,2
]}

机构：

[1] Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada 18071, Spain

[2] Inst Invest Biosanit Granada Ibs GRANADA, Granada 18012, Spain

[3] Univ Perugia, Dept Med & Surg, I-06132 Perugia, Italy

[4] Ctr Salud Floridablanca, Murcia 30002, Spain

[5] Hosp Univ Clin San Cecilio, Serv Microbiol, Granada 18100, Spain

[6] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid 28029, Spain

[7] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain

[8] Inst Murciano Invest & Desarrollo Agr & Alimentari, Murcia 30150, Spain

[9] Inst Murciano Invest Biosanit IMIB Arrixaca, Murcia 30120, Spain

[10] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain

来源：

ANTIOXIDANTS | 2023年 / 12卷 / 04期

关键词：

Morus alba L; obesity; microbiota; antioxidant; OXIDATIVE STRESS; ADIPOSE-TISSUE; LIPID-PEROXIDATION; ENERGY-EXPENDITURE; UCP1; EXPRESSION; INFLAMMATION; ADIPOCYTES; GUIDELINES; RESISTANCE; QUERCETIN;

D O I：

10.3390/antiox12040978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis.

引用

页数：19