A new iridoid from the roots of Valeriana jatamansi Jones with a-glucosidase activity

被引：5

作者：

Maurya, Antim K. K. ^{[1
,2
,3
]}

Agnihotri, Vijai K. K. ^{[1
,2
]}

机构：

[1] CSIR, Inst Himalayan Bioresource Technol, Chem Technol Div, Palampur, Himachal Prades, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad, India

[3] Univ Mississippi, Dept Biomol Sci, Oxford, MS USA

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 14期

关键词：

Valeriana jatamansi; iridoids; rupesin F; alpha-glucosidase;

D O I：

10.1080/14786419.2023.2187796

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new iridoid namely rupesin F (1) together with four known ones (2-5) were isolated from the roots of Valeriana jatamansi Jones. The structures were established using spectroscopic methods (1D and 2D NMR including HSQC, HMBC, COSY and NOESY) and by comparison with previously published literature data. The isolated compounds 1 and 3 exhibited strong alpha-glucosidase inhibition activity with IC50 values of 10.13 +/- 0.11 and 9.13 +/- 0.03 mu g/mL, respectively. This study enriched the chemical diversity of metabolites and provides a direction for the development of antidiabetic agents.

引用

页码：2505 / 2510

页数：6

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