Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

被引：2

作者：

Groenen, Patricia J. T. A. ^{[1
,2
]}

van den Brand, Michiel ^{[1
,3
]}

Kroeze, Leonie I. ^{[1
,2
]}

Amir, Avital L. ^{[1
]}

Hebeda, Konnie M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Dept Pathol, Med Ctr, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands

[3] Locat Rijnstate Hosp, Pathol DNA, Arnhem, Netherlands

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

immunoglobulin E; T-cell receptor; gene rearrangement; clonality assessment; NGS; pathology; B-CELL LYMPHOMA; POLYMERASE-CHAIN-REACTION; PERIPHERAL T-CELL; CLASSICAL HODGKIN LYMPHOMA; EPSTEIN-BARR-VIRUS; FOLLICULAR LYMPHOMA; GENE REARRANGEMENTS; SALIVARY-GLANDS; LATE RELAPSE; TRANSFORMATION;

D O I：

10.3389/fonc.2023.1107171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonality assessment using the unique rearrangements of immunoglobulin (IG) and T-cell receptor (TR) genes in lymphocytes is a widely applied supplementary test for the diagnosis of B-cell and T-cell lymphoma. To enable a more sensitive detection and a more precise comparison of clones compared with conventional clonality analysis based on fragment analysis, the EuroClonality NGS Working Group developed and validated a next-generation sequencing (NGS)-based clonality assay for detection of the IG heavy and kappa light chain and TR gene rearrangements for formalin-fixed and paraffin-embedded tissues. We outline the features and advantages of NGS-based clonality detection and discuss potential applications for NGS-based clonality testing in pathology, including site specific lymphoproliferations, immunodeficiency and autoimmune disease and primary and relapsed lymphomas. Also, we briefly discuss the role of T-cell repertoire of reactive lymphocytic infiltrations in solid tumors and B-lymphoma.

引用

页数：7

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