Nano-vitamin C: A promising candidate for therapeutic applications

被引:18
作者
Bedhiafi, Takwa [1 ]
Idoudi, Sourour [2 ]
Fernandes, Queenie [1 ,3 ]
Al-Zaidan, Lobna [1 ]
Uddin, Shahab [4 ,5 ,6 ]
Dermime, Said [1 ,7 ,8 ]
Billa, Nashiru [2 ]
Merhi, Maysaloun [1 ,7 ]
机构
[1] Hamad Med Corp, Translat Res Inst, Translat Canc Res Facil, Doha, Qatar
[2] Qatar Univ, Coll Pharm, Doha, Qatar
[3] Qatar Univ, Coll Med, Doha, Qatar
[4] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, Doha, Qatar
[5] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, Doha, Qatar
[6] Qatar Univ, Lab Anim Res Ctr, Doha, Qatar
[7] Hamad Med Corp, Natl Ctr Canc Care & Res, Doha, Qatar
[8] Hamad Bin Khalifa Univ, Coll Hlth & Life Sci, Doha, Qatar
关键词
Vitamin C; Nano-vitamin C; Therapeutic; Clinical; Nanomedicine; WATER-SOLUBLE VITAMINS; ASCORBIC-ACID; DRUG-DELIVERY; GOLD NANOPARTICLES; SOLID DISPERSIONS; STABILITY; ENCAPSULATION; LIPOSOMES; DEGRADATION; BIOMARKERS;
D O I
10.1016/j.biopha.2022.114093
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by low chemical stability. Several nano-encapsulation techniques have been described in the literature and yet, there are only a handful of clinical investigations dedicated to unlocking the therapeutic applications of nano -encapsulated vitamin C. Clearly, further investigations are warranted in order to affirm the promising clinical potential of nano-encapsulated vitamin C. In this review, we describe the mechanisms of vitamin C activity as a modulator of crucial therapeutic uses in biological systems. We look at key factors affecting the chemical stability of vitamin C alone and in nano-encapsulated and explore pre-clinical and clinical evidence on current vitamin C nano-formulations along with their therapeutic applications. Finally, we critically appraise the gaps and op-portunities prevailing in nano-vitamin C research and its potential translation towards relevant clinical outcomes.
引用
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页数:8
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