Adagrasib with or without cetuximab in patients with KRASG12C-mutated colorectal cancer (CRC): Analysis of tumor biomarkers and genomic alterations

被引：3

作者：

Pelster, M. S. ^{[1
]}

Yaeger, R. ^{[2
]}

Klempner, S. J. ^{[3
]}

Ou, S-H. I. ^{[4
]}

Spira, A. I. ^{[5
,6
]}

Janne, P. A. ^{[7
]}

Uboha, N. V. ^{[8
]}

Gaffar, Y. A. ^{[9
]}

Newman, G. ^{[10
]}

Paweletz, C. P. ^{[11
]}

Heavey, G. A. ^{[12
]}

Alejandro, L. ^{[13
]}

Kheoh, T. ^{[14
]}

Anderes, K. ^{[15
]}

Torossian, H. Der ^{[16
]}

Christensen, J. G. ^{[17
]}

Weiss, J. ^{[18
]}

机构：

[1] Sarah Cannon Res Inst, Gastrointestinal Res, Nashville, TN USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA

[3] Massachusetts Gen Canc Ctr, Dept Med, Boston, MA USA

[4] UCI Hlth Chao Family Comprehens Canc Ctr, Dept Med, Orange, CA USA

[5] Virginia Canc Specialist, Res Inst, Fairfax, VA USA

[6] US Oncol Res, The Woodlands, TX USA

[7] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA USA

[8] Univ Wisconsin, Med, Madison, TX USA

[9] Maryland Oncol Hematol, Med Oncol, Columbia, MD 8 USA

[10] Ridley Tree Canc Ctr, Clin Res, Santa Barbara, CA USA

[11] Dana Farber Canc Inst, Med Oncol, Boston, MA USA

[12] Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA USA

[13] Mirati Therapeut Inc, Med Affairs, San Diego, CA USA

[14] Mirati Therapeut Inc, Biometr, San Diego, CA USA

[15] Mirati Therapeut Inc, Translat Med & Compan Diagnost, San Diego, CA USA

[16] Mirati Therapeut Inc, Clin Dev, San Diego, CA USA

[17] Mirati Therapeut Inc, San Diego, CA USA

[18] Univ N Carolina, Lineberger Comprehens Canc Ctr, Oncol, Chapel Hill, NC USA

来源：

ANNALS OF ONCOLOGY | 2023年 / 34卷

关键词：

D O I：

10.1016/j.annonc.2023.09.1740

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

549O

引用

页码：S410 / S410

页数：1

共 50 条

[1] Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Yaeger, Rona
Uboha, Nataliya V.
Pelster, Meredith S.
Bekaii-Saab, Tanios S.
Barve, Minal
Saltzman, Joel
Sabari, Joshua K.
Peguero, Julio A.
Paulson, Andrew Scott
Janne, Pasi A.
Cruz-Correa, Marcia
Anderes, Kenna
Velastegui, Karen
Yan, Xiaohong
Der-Torossian, Hirak
Klempner, Samuel J.
Kopetz, Scott E.
CANCER DISCOVERY, 2024, 14 (06) : 982 - 993
[2] Adagrasib: A landmark in the KRASG12C-mutated NSCLC
Tian, He
Yang, Zhenlin
He, Jie
MEDCOMM, 2022, 3 (04):
[3] Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C
Yaeger, Rona
Weiss, Jared
Pelster, Meredith S.
Spira, Alexander, I
Barve, Minal
Ou, Sai-Hong, I
Leal, Ticiana A.
Bekaii-Saab, Tanios S.
Paweletz, Cloud P.
Heavey, Grace A.
Christensen, James G.
Velastegui, Karen
Kheoh, Thian
Der-Torossian, Hirak
Klempner, Samuel J.
NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (01) : 44 - 54
[4] Adagrasib (Ada) plus cetuximab (Cetux) for KRASG12C-mutated metastatic colorectal cancer (mCRC): Longer follow-up analysis from KRYSTAL-1.
Yaeger, Rona
Uboha, Nataliya V.
Klempner, Samuel J.
Bekaii-Saab, Tanios S.
Sabari, Joshua K.
Barve, Minal A.
Saltzman, Joel N.
Peguero, Julio Antonio
Paulson, Andrew Scott
Janne, Pasi A.
Pelster, Meredith
Cruz-Correa, Marcia
Kim, Amy Min Kyung
Hu, Nan
Ahmad, Harris A.
Kopetz, Scott
JOURNAL OF CLINICAL ONCOLOGY, 2025, 43 (4_SUPPL) : 131 - 131
[5] Adagrasib: a novel inhibitor for KRASG12C-mutated non-small-cell lung cancer
Guo, Matthew Z.
Marrone, Kristen A.
Spira, Alexander
Rosner, Samuel
FUTURE ONCOLOGY, 2023, 19 (15) : 1037 - 1051
[6] Targeting KRASG12C-Mutated Advanced Colorectal Cancer: Research and Clinical Developments
不详
ONCOTARGETS AND THERAPY, 2022, 15 : 747 - 756
[7] Sotorasib Tackles KRASG12C-Mutated Pancreatic Cancer
Osterweil, Neil
CANCER DISCOVERY, 2022, 12 (04) : 878 - 879
[8] Coexisting Genomic Alterations in Risk Stratification of KRASG12C-Mutated Non-Small Cell Lung Cancer
Heng, Sarina Z. W.
Hoo, Regina
Tan, Daniel S. W.
CANCER DISCOVERY, 2023, 13 (07) : 1513 - 1515
[9] KRYSTAL-1: Updated efficacy and safety of adagrasib (MRTX849) with or without cetuximab in patients with advanced colorectal cancer (CRC) harboring a KRASG12C mutation
Klempner, S. J.
Weiss, J.
Pelster, M.
Spira, A.
Barve, M.
Ou, S-H. I.
Leal, A.
Bekaii-Saab, T.
Christensen, J. G.
Kheoh, T.
Velastegui, K.
Torossian, H. Der
Yaeger, R.
ANNALS OF ONCOLOGY, 2022, 33 (07) : S1391 - S1391
[10] Practical Guidance for the Management of Adverse Events in Patients with KRASG12C-Mutated Non-Small Cell Lung Cancer Receiving Adagrasib
Zhang, Jun
Johnson, Melissa
Barve, Minal
Bazhenova, Lyudmila
McCarthy, Marybeth
Schwartz, Rowena
Horvath-Walsh, Elise
Velastegui, Karen
Qian, Chunlin
Spira, Alexander
ONCOLOGIST, 2023, : 287 - 296

← 1 2 3 4 5 →