Effects of low-frequency rTMS combined with risperidone on the gut microbiome in hospitalized patients with chronic schizophrenia

被引：5
作者：
Li, Rui [1 ]
Fu, Rui [1 ]
Cui, Zhi-quan [1 ]
Guo, Lin [1 ]
Chen, Yi-huan [2 ]
Bai, Jie [3 ]
Yang, Jia-bin [1 ]
Tan, Qing-rong [1 ]
Peng, Zheng-wu [1 ,2 ]
机构：
[1] Changan Hosp, Dept Psychiat, Xian 710000, Peoples R China
[2] Air Force Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
[3] Gaoxin Hosp, Dept Psychiat, Xian 710077, Peoples R China
来源：
BRAIN RESEARCH | 2023年 / 1819卷
基金：
中国国家自然科学基金;
关键词：
rTMS; Risperidone; Gut microbiota; Chronic schizophrenia; TRANSCRANIAL MAGNETIC STIMULATION; HALLUCINATIONS; SEVERITY; EFFICACY;
D O I：
10.1016/j.brainres.2023.148539
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Repetitive transcranial magnetic stimulation (rTMS) has been widely used in treating schizophrenia (SCH). However, the effects of the low frequency of rTMS combined with antipsychotics on the gut microbiome in chronic SCH have been poorly investigated. In the present study, psychiatric symptoms were assessed and the stool samples obtained from 33 adult patients with chronic SCH (at baseline phase), 27 after 2 weeks of treatment (rTMS combined with risperidone, SCH-2W), and 37 healthy controls (HC) were analyzed by 16S rRNA gene sequencing. We found that the reduction of phylum Proteobacteria, family Enterobacteriaceae and genera Escherichia-Shigella as well as the increase of genera norank_f_Lachnospiraceae might be related to the antipsychotic effect of rTMS combined with risperidone. These findings indicate that the brain-gut-microbiota axis might be involved in the therapeutic effect of rTMS combined with antipsychotic drugs.
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页数：8
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