Research Progress Into Adipose Tissue Macrophages and Insulin Resistance

被引：4
作者：
Fu, Mengfei [1 ,2 ]
Yang, Liu [1 ,2 ]
Wang, Hanyu [1 ,2 ]
Chen, Yang [1 ,2 ]
Chen, Xiao [1 ,2 ]
Hu, Qinyu [1 ,2 ]
Sun, Hui [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China
[2] Hubei Prov Clin Res Ctr Diabet & Metab Disorders, Wuhan, Peoples R China
来源：
PHYSIOLOGICAL RESEARCH | 2023年 / 72卷 / 03期
关键词：
Insulin resistance; Adipose tissue; Inflammation; Adipose tissue macrophages; Phenotype; TUMOR-NECROSIS-FACTOR; ALTERNATIVE ACTIVATION; ADIPOCYTE DEATH; FACTOR-ALPHA; PPAR-GAMMA; IN-VIVO; POLARIZATION; INFLAMMATION; OBESITY; TLR4;
D O I：
10.33549/physiolres.935046
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
In recent years, there has been an increasing incidence of metabolic syndrome, type 2 diabetes, and cardiovascular events related to insulin resistance. As one of the target organs for insulin, adipose tissue is essential for maintaining in vivo immune homeostasis and metabolic regulation. Currently, the specific adipose tissue mechanisms involved in insulin resistance remain incompletely understood. There is increasing evidence that the process of insulin resistance is mostly accompanied by a dramatic increase in the number and phenotypic changes of adipose tissue macrophages (ATMs). In this review, we discuss the origins and functions of ATMs, some regulatory factors of ATM phenotypes, resistance in adipose tissue. We expect that modulation of ATM diseases associated with insulin resistance.
引用
收藏
页码：287 / 299
页数：13
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