Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures

被引:33
作者
Wang, Bin [1 ,2 ,3 ,4 ]
Liu, Wei [1 ,2 ,3 ,4 ]
Yu, Linling [1 ,2 ,3 ,4 ]
Ye, Zi [1 ,2 ,3 ,4 ]
Cheng, Man [1 ,5 ]
Qiu, Weihong [1 ,6 ]
Zhou, Min [1 ,2 ,3 ,4 ]
Ma, Jixuan [1 ,2 ,3 ,4 ]
Wang, Xing [1 ,2 ,3 ,4 ]
Yang, Meng [7 ]
Song, Jiahao [1 ,2 ,3 ,4 ]
Chen, Weihong [1 ,2 ,3 ,4 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
[6] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Fuzhou 350122, Peoples R China
[7] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Hlth Care Hosp, Tongji Med Coll, Wuhan 430019, Hubei, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
acrolein; environmental health; glucose homeostasis; type; 2; diabetes; mediating mechanism; oxidative stress; VOLATILE ORGANIC-COMPOUNDS; EXHALED CARBON-MONOXIDE; OXIDATIVE DNA-DAMAGE; PROTEIN CARBONYLATION; STRESS; METABOLITES; ASSOCIATIONS; BIOMARKERS;
D O I
10.1021/acs.est.2c09299
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Acrolein is an identified high-priority hazardous air pollutant ubiquitous in daily life and associated with cardiometabolic risk that attracts worldwide attention. However, the etiology role of acrolein exposure in glucose dyshomeostasis and type 2 diabetes (T2D) is unclear. This repeated-measurement prospective cohort study included 3522 urban adults. Urine/blood samples were repeatedly collected for determinations of acrolein metabolites (N-acetyl-S-(3-hydroxypropyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine; acrolein exposure biomarkers), glucose homeostasis, and T2D at baseline and a three-year follow-up. We found that each 3-fold increment in acrolein metabolites was cross-sectionally associated with 5.91-6.52% decrement in homeostasis model assessment-insulin sensitivity (HOMA-IS) and 0.07-0.14 mmol/L, 4.02-4.57, 5.91- 6.52, 19-20, 18-19, and 23-31% increments in fasting glucose (FPG), fasting insulin (FPI), HOMA-insulin resistance (HOMA-IR), risks of prevalent IR, impaired fasting glucose (IFG), and T2D, respectively; longitudinally, participants with sustained-high acrolein metabolite levels had increased risks of incident IR, IFG, and T2D by 63-80, 87-99, and 120-154%, respectively (P < 0.05). In addition, biomarkers of heme oxygenase-1 activity (exhaled carbon monoxide), lipid peroxidation (8-iso-prostaglandin-F2 alpha), protein carbonylation (protein carbonyls), and oxidative DNA damage (8-hydroxy-deoxyguanosine) mediated 5.00-38.96% of these associations. Our study revealed that acrolein exposure may impair glucose homeostasis and increase T2D risk via mediating mechanisms of heme oxygenase-1 activation, lipid peroxidation, protein carbonylation, and oxidative DNA damage.
引用
收藏
页码:7162 / 7173
页数:12
相关论文
共 55 条
[1]   Acrolein Exposure in US Tobacco Smokers and Non-Tobacco Users: NHANES 2005-2006 [J].
Alwis, K. Udeni ;
deCastro, B. Rey ;
Morrow, John C. ;
Blount, Benjamin C. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2015, 123 (12) :1302-1308
[3]   Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis [J].
Anandhan, Annadurai ;
Dodson, Matthew ;
Schmidlin, Cody J. ;
Liu, Pengfei ;
Zhang, Donna D. .
CELL CHEMICAL BIOLOGY, 2020, 27 (04) :436-447
[4]   Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity [J].
Ansari, Mubeen A. ;
Keller, Jeffrey N. ;
Scheff, Stephen W. .
FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 (11) :1510-1519
[5]  
Ashizawa A., 2007, Toxicological profile for acrolein
[6]   Models with Transformed Variables Interpretation and Software [J].
Barrera-Gomez, Jose ;
Basagana, Xavier .
EPIDEMIOLOGY, 2015, 26 (02) :E16-E17
[7]   Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases Heme Oxygenase 1 Transcripts [J].
Bein, Kiflai ;
Birru, Rahel L. ;
Wells, Heather ;
Larkin, Theodore P. ;
Cantrell, Pamela S. ;
Fagerburg, Matthew, V ;
Zeng, Xuemei ;
Leikauf, George D. .
CHEMICAL RESEARCH IN TOXICOLOGY, 2020, 33 (07) :1969-1979
[8]   Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men [J].
Boden, Guenther ;
Homko, Carol ;
Barrero, Carlos A. ;
Stein, T. Peter ;
Chen, Xinhua ;
Cheung, Peter ;
Fecchio, Chiara ;
Koller, Sarah ;
Merali, Salim .
SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (304)
[9]   Total, Direct, and Indirect Effects in Logit and Probit Models [J].
Breen, Richard ;
Karlson, Kristian Bernt ;
Holm, Anders .
SOCIOLOGICAL METHODS & RESEARCH, 2013, 42 (02) :164-191
[10]   Ambient Acrolein Concentrations in Coastal, Remote, and Urban Regions in California [J].
Cahill, Thomas M. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2014, 48 (15) :8507-8513