Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

被引：80

作者：

Zhao, Mengnan ^{[1
]}

Wang, Rujing ^{[1
]}

Yang, Kunmeng ^{[2
]}

Jiang, Yuhong ^{[3
]}

Peng, Yachen ^{[4
,5
]}

Li, Yuke ^{[1
]}

Zhang, Zhen ^{[1
]}

Ding, Jianxun ^{[4
]}

Shi, Sanjun ^{[1
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China

[2] Jilin Univ, Norman Bethune Coll Clin Med 1, Changchun 130061, Peoples R China

[3] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

[4] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[5] Jilin Univ, Dept Orthoped, China Japan Union Hosp, Changchun 130033, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2023年 / 13卷 / 03期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

Nucleic acid; RNA nanotechnology; DNA tetrahedron; TETRAHEDRAL DNA NANOSTRUCTURE; ROLLING CIRCLE AMPLIFICATION; CYTOTOXIC T-LYMPHOCYTES; IN-VIVO DELIVERY; MESSENGER-RNA; MICRORNA DETECTION; BUILDING-BLOCKS; EMERGING FIELD; ELECTROCHEMILUMINESCENCE BIOSENSOR; ORIGAMI NANOSTRUCTURES;

D O I：

10.1016/j.apsb.2022.10.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging. Recently, more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating. Due to the flexibility and deformability of nucleic acids, the nanoassemblies could be fabricated with different shapes and structures. With hybridization, nucleic acid nanoassemblies, including DNA and RNA nanostructures, can be applied to enhance RNA therapeutics and diagnosis. This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development.

引用

页码：916 / 941

页数：26

共 312 条

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