Zinc homeostasis in Pseudomonas

被引：15

作者：

Ducret, Verena ^{[1
]}

Gonzalez, Diego ^{[2
]}

Perron, Karl ^{[1
,3
]}

机构：

[1] Univ Geneva, Dept Plant Sci, Microbiol Unit, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland

[2] Univ Neuchatel, Fac Sci, Inst Biol, Lab Microbiol, Rue Emile Argand 11, CH-2000 Neuchatel, Switzerland

[3] Univ Geneva, Sect Pharmaceut Sci, Rue Michel Servet 1, CH-1205 Geneva, Switzerland

来源：

BIOMETALS | 2023年 / 36卷 / 04期

关键词：

Metal transporters; Zinc homeostasis; Pseudomonas; RND; CzcR; CzcS; CzcCBA; CadR; Zur; ZnuABC; Pseudopaline; P-type ATPase; CDF; ABC-transporters; HEAVY-METAL RESISTANCE; TRANSCRIPTIONAL REGULATOR; TRANSITION-METALS; ION-TRANSPORT; BINDING; COPPER; DIVERSITY; SYSTEMS; FAMILY; METALLOTHIONEIN;

D O I：

10.1007/s10534-022-00475-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the genus Pseudomonas, zinc homeostasis is mediated by a complete set of import and export systems, whose expression is precisely controlled by three transcriptional regulators: Zur, CzcR and CadR. In this review, we describe in detail our current knowledge of these systems, their regulation, and the biological significance of zinc homeostasis, taking Pseudomonas aeruginosa as our paradigm. Moreover, significant parts of this overview are dedicated to highlight interactions and cross-regulations between zinc and copper import/export systems, and to shed light, through a review of the literature and comparative genomics, on differences in gene complement and function across the whole Pseudomonas genus. The impact and importance of zinc homeostasis in Pseudomonas and beyond will be discussed throughout this review.

引用

页码：729 / 744

页数：16

共 92 条

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