The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture

被引：5
作者：
Jacobs, Cale A. [1 ]
Olsen, Zachary M. [2 ]
Marchand, Lucas S. [2 ]
Kraus, Virginia B. [3 ,4 ]
Anderson, Donald D. [5 ]
Haller, Justin [2 ]
机构：
[1] Brigham & Womens Hosp, Massachusetts Gen Brigham Sports Med, 20 Patriot Pl, Foxboro, MA 02035 USA
[2] Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT USA
[3] Duke Univ, Duke Mol Physiol Inst, Durham, NC USA
[4] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA
[5] Univ Iowa, Dept Orthoped & Rehabil, Iowa City, IA USA
来源：
INFLAMMATION RESEARCH | 2023年 / 72卷 / 01期
关键词：
Fracture; Tibia; Knee; Ankle; Inflammation; Cytokine;
D O I：
10.1007/s00011-022-01661-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1 beta, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.
引用
收藏
页码：9 / 11
页数：3
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