Separation of a new triterpenoid saponin together with six known ones from Clematis tangutica (Maxim.) Korsh and evaluation of their cytotoxic activities

被引：4

作者：

Wei, Yangfei ^{[1
,2
,3
]}

Chen, Tao ^{[1
,2
]}

Wang, Shuo ^{[1
]}

Shen, Cheng ^{[1
,2
]}

Yan, Shuping ^{[1
,2
]}

Song, Zhibo ^{[1
,2
]}

Liu, Yarong ^{[4
]}

Yang, Fengmei ^{[4
]}

Hai, Ping ^{[4
]}

Li, Yulin ^{[1
]}

机构：

[1] Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China

[2] Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China

[3] Hexi Univ, Key Lab Hexi Corridor Resources Utilizat Gansu, Zhangye, Peoples R China

[4] Qinghai Inst Food & Drug Control, Xining, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 03期

关键词：

Clematis tangutica (Maxim; ) Korsh; triterpenoid saponins; new compound; high-speed counter-current chromatography; cytotoxic activities; CONSTITUENTS;

D O I：

10.1080/14786419.2021.1984468

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new triterpenoid saponin, 3-O-beta-D-allopyranosyl (1 -> 3)-alpha-L-rhamnopyranosyl (1 -> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1 -> 4)-beta-D-glucopyranosyl (1 -> 6)-beta-D-glucopyranosyl ester (IV), together with six known ones Hederacholichiside F (I), Tanguticoside B (II), Tauroside St-H-1 (III), Hederoside H-1 (V), Kalopanaxsaponin G (VI), Hederasaponin B (VII) were separated from Clematis tangutica (Maxim.) Korsh. Their cytotoxic activities were evaluated. Saponins IV (new compound) and I showed selective inhibitory activities against HGC-27 with IC50 values of 20.17 and 66.18 mu M. Saponin VII exhibited extensive inhibitory action against HGC-27, Hela and SK-OV-3 with IC50 values of 16.47-71.36 mu M. Saponin III showed selective inhibitory activity against SK-OV-3 with the IC50 value of 48.70 mu M. All isolated saponins were inactive (IC50 >150 mu M) to GES-1.

引用

页码：375 / 382

页数：8

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