Point-of-care testing for D-dimer in the exclusion of venous thromboembolism: a critical analysis

被引：1

作者：

Grand, Francois ^{[1
]}

Blanc-Jouvan, Florence ^{[2
]}

Delassasseigne, Celine ^{[3
]}

Galinat, Hubert ^{[4
]}

Roy, Pierre-Marie ^{[5
]}

Talon, Laurie ^{[6
]}

Toussaint-Hacquard, Marie ^{[7
]}

Macchi, Laurent ^{[1
]}

机构：

[1] Univ Poitiers, Lab Hematol Biol, CHU Poitiers, 2 Rue Miletrie, F-86000 Poitiers, France

[2] Ctr Hosp Annecy Genevois, Lab dhematol, 1 Ave Hop, F-74370 Epagny Metz Tessy, France

[3] Hop Haut Leveque, Lab Hematol, CHU Bordeaux, Ave Magellan, F-33604 Pessac, France

[4] CHU Brest, Lab Hematol, Blvd Tanguy Prigent, F-29200 Brest, France

[5] Univ Angers, UMR MitoVasc CNRS 6015, Dept Med Urgence, Equipe CARME,INSERM 1083, 4 Rue Larrey, F-49000 Angers, France

[6] CHU Clermont Ferrand, Serv Hematol Biol, 1 Pl Lucie Aubrac, F-63003 Clermon Ferrand, France

[7] CHU Nancy, Lab Hematol Biol, Rue Morvan, F-54511 Vandoeuvre Les Nancy, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2023年 / 81卷 / 05期

关键词：

D-dimer; POCT; point of care testing; venous thromboembolism; DIAGNOSTIC WORK-UP; CARDIAC D-DIMER; PULMONARY-EMBOLISM; WHOLE-BLOOD; ASSAY; ACCURACY; STANDARDIZATION; COMMUNICATION; SPECIFICITY; THROMBOSIS;

D O I：

10.1684/abc.2023.1839

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Point-of-care testing (POCT) for D-dimer is an alternative to laboratory testing for the exclusion of venous thromboembolism (VTE). This critical review by the "CEC et biologie delocalisee" working group of the "Societe Francaise de Thrombose et d'Hemostase" (French Society of Thrombosis and Haemostasis) aims to present the characteristics of six POCT D-dimer assays available in France in 2023. The article highlights the need to define VTE exclusion thresholds specific to each technique and validated by clinical studies. There is insufficient data to validate the use of cut off suggested by manufacturers, and age-adjusted thresholds. The article discusses the role of laboratories in justifying and prescribing POCT D-dimer, according to objective criteria, such as the availability and turnaround time of classical laboratory tests. They should also encourage rational prescribing, limited to patients with low risk of venous thromboembolism, following an assessment of clinical probability according to national and international guidelines.

引用

页码：461 / 474

页数：14

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