Menstrual cycle alterations in reproductive age women after anti COVID-19 vaccination A survey in 419 Italian women and quality of life and sexual function evaluation

被引:0
作者
Loggia, Melania [1 ,6 ]
DI Pinto, Anna [2 ]
Morgani, Claudia [1 ]
Cardella, Giorgia [1 ]
Contadini, Alessia [1 ]
Palazzetti, Pier L.
Macri, Francesca
Moro, Paolo R. [2 ]
Spina, Vincenzo [3 ]
Morciano, Andrea [4 ,5 ]
Valensise, Herbert C. [1 ]
Schiavi, Michele C.
机构
[1] Sandro Pertini Hosp, Dept Gynecol & Obstet, Rome, Italy
[2] Tor Vergata Univ, Sect Gynecol & Obstet, Dept Surg Sci, Rome, Italy
[3] Anzio Hosp, Dept Gynecol & Obstet, Anzio, Rome, Italy
[4] Protect Maternal & Child Hlth Unit, I-02100 Rieti, Italy
[5] Cardinal Pan Hosp, Dept Obstet & Gynecol, Tricase, Lecce, Italy
[6] Tor Vergata Univ, Sandro Pertini Hosp, Dept Obstet & Gynecol, Via Monti Tiburtini 385-389, I-00157 Rome, Italy
关键词
COVID-19; Adverse effects; Menstrual cycle; Menstruation disturbances; Vaccines; DISTRESS; SCALE;
D O I
10.23736/S2724-606X.23.05347-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Pharmacovigilance agencies did not collect data regarding menstrual changes after COVID-19 vaccination even if many women experienced it. Our aim was to evaluate whether COVID-19 vaccination is associated with secondary changes in menstrual cycle and to assess both quality of life (QoL) and sexual function (SF).METHODS: This study is a retrospective analysis referred to our Department from January 2021 to December 2021. The study cohort responded to same questionnaires before the second dose of vaccination (referring to previous 3 months) and 3 months after that (referring to three menstrual cycles after full-dose vaccination). The surveys administered were FSFI, FSDS, SF-36, MEDI-Q and the VAS-scale for dysmenorrhea.RESULTS: Four-hundred-nineteen vaccinated women were included in the study. The survey did not show a significant change in menstrual cycle length before and after COVID-19 vaccine (5.88 +/- 3.67 vs. 4.97 +/- 2.89, P=0.21); the interval between periods was significantly higher after a full-cycle vaccination (28.32 +/- 7.34 vs. 32.38 +/- 7.45, P<0.02); 32 patients (7.6%) developed amenorrhea after the second dose; VAS Scale did not change significantly (median range 3 (3-5) vs. 4 (3-6), P=0.20). MEDI-Q did not show significant variations before and after the vaccination (43.21 +/- 11.65 vs. 40.28 +/- 9.88, P=0.35). QoL and SF did not change significantly (FSFI median 27 [24-29] vs. 28 [25-30], P=0.12, FSDS median 9 [5-11] vs. 8 [4-12], P=0.22), SF-36 median 81 [70-85] vs. 82 [72-86], P=0.43).CONCLUSIONS: COVID-19 vaccination is associated with a significant change in intervals between menstrual cycles without other alterations in menstrual characteristics, in QoL or SF.
引用
收藏
页码:516 / 521
页数:6
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