Cu2Se-based injectable hydrogels for synergistic photothermal/gas therapy of oral squamous cell carcinoma

被引：11
作者：
Zhong, Nanping [1 ,2 ]
Xing, Jianghao [2 ,3 ]
He, Jia [2 ,4 ]
Zhao, Xinyu [2 ,4 ]
Wang, Xianwen [2 ,5 ]
Xue, Haowei [1 ,2 ]
机构：
[1] Anhui Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, Hefei 230032, Peoples R China
[2] Anhui Med Univ, Coll Biomed Engn, Hefei 230032, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230032, Peoples R China
[4] Anhui Med Univ, Affiliated Hosp 1, Dept Wound & Burn, Hefei 230032, Peoples R China
[5] Anhui Med Univ, Sch Oral Med, Anhui Prov Key Lab Oral Dis Res, Hefei 230032, Peoples R China
来源：
MATERIALS & DESIGN | 2024年 / 237卷
基金：
中国国家自然科学基金;
关键词：
Cu 2 Se nanosheets; Injectable hydrogel; Oral squamous cell carcinoma; Photothermal therapy; Gas therapy;
D O I：
10.1016/j.matdes.2023.112535
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Oral squamous cell carcinoma (OSCC) produces malignant tumours in the oral cavity and adjacent anatomical structures, ranking sixth among the 11 most common malignant tumours in the body. The poor surgical outcomes for OSCC have led to increasing interest in nanomedicines. Major challenges with concentrationdependent therapies include the effective and precise delivery of gases to the lesion and combination with other therapies to achieve precise treatment. Herein, novel Cu2Se nanosheets (Cu2Se NSs) were ingeniously synthesized and enveloped with a thermosensitive nitric oxide (NO) supplier (sodium nitroprusside dihydrate, SNP) within a sodium alginate (ALG) hydrogel matrix to effectively eradicate tumours by combining photothermal therapy (PTT) and gas therapy (GT). The Cu2Se NSs reduced the glutathione (GSH) present in high concentrations to glutathione disulfide (GSSG), effectively killing squamous cell carcinoma cells under 1064 nm laser irradiation. Moreover, the Cu2Se NS hydrogel wrapped with SNP exhibited good NIR-controlled NO release behaviour, thus realizing the combined application of PTT and GT. PTT along with NO release is expected to improve the antitumour effect and provide new solutions for treating OSCC.
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页数：12
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